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COH34

CAS No. 906439-72-3

COH34( -[(E)-(4-methylphenyl)sulfanyliminomethyl]naphthalen-2-ol )

Catalog No. M26126 CAS No. 906439-72-3

COH34 is a selective inhibitor of PARG with an IC50 of 0.37 nM and a Kd of 0.547 μM. COH34 prolongs PARylation at DNA lesions and traps DNA repair factors.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    COH34
  • Note
    Research use only, not for human use.
  • Brief Description
    COH34 is a selective inhibitor of PARG with an IC50 of 0.37 nM and a Kd of 0.547 μM. COH34 prolongs PARylation at DNA lesions and traps DNA repair factors.
  • Description
    COH34 is a selective inhibitor of PARG with an IC50 of 0.37 nM and a Kd of 0.547 μM. COH34 prolongs PARylation at DNA lesions and traps DNA repair factors.(In Vitro):COH34 potently inhibits PARP inhibitor-resistant cancer cells.(In Vivo):COH34 shows antitumor activity in xenograft mouse cancer models.
  • In Vitro
    COH34 efficiently kills PARP inhibitor-resistant cancer cells.
  • In Vivo
    COH34 induces lethality in cancer cells with DNA repair defects and exhibits antitumor activity in xenograft mouse cancer models.
  • Synonyms
    -[(E)-(4-methylphenyl)sulfanyliminomethyl]naphthalen-2-ol
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Cytidine deaminase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    906439-72-3
  • Formula Weight
    293.38
  • Molecular Formula
    C18H15NOS
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 16.67 mg/mL (56.82 mM)
  • SMILES
    Cc1ccc(S\N=C\c2c(O)ccc3ccccc23)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Funamizu N, et al. Tetrahydrouridine inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels. PLoS One. 2012;7(5):e37424.
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