Cart
sales@molnova.com
COH34
CAS No. 906439-72-3
COH34( -[(E)-(4-methylphenyl)sulfanyliminomethyl]naphthalen-2-ol )
Catalog No. M26126 CAS No. 906439-72-3
COH34 is a selective inhibitor of PARG with an IC50 of 0.37 nM and a Kd of 0.547 μM. COH34 prolongs PARylation at DNA lesions and traps DNA repair factors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 260 | Get Quote |
|
| 10MG | 410 | Get Quote |
|
| 25MG | 678 | Get Quote |
|
| 50MG | 954 | Get Quote |
|
| 100MG | 1287 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameCOH34
-
NoteResearch use only, not for human use.
-
Brief DescriptionCOH34 is a selective inhibitor of PARG with an IC50 of 0.37 nM and a Kd of 0.547 μM. COH34 prolongs PARylation at DNA lesions and traps DNA repair factors.
-
DescriptionCOH34 is a selective inhibitor of PARG with an IC50 of 0.37 nM and a Kd of 0.547 μM. COH34 prolongs PARylation at DNA lesions and traps DNA repair factors.(In Vitro):COH34 potently inhibits PARP inhibitor-resistant cancer cells.(In Vivo):COH34 shows antitumor activity in xenograft mouse cancer models.
-
In VitroCOH34 efficiently kills PARP inhibitor-resistant cancer cells.
-
In VivoCOH34 induces lethality in cancer cells with DNA repair defects and exhibits antitumor activity in xenograft mouse cancer models.
-
Synonyms-[(E)-(4-methylphenyl)sulfanyliminomethyl]naphthalen-2-ol
-
PathwayOthers
-
TargetOther Targets
-
RecptorCytidine deaminase
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number906439-72-3
-
Formula Weight293.38
-
Molecular FormulaC18H15NOS
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 16.67 mg/mL (56.82 mM)
-
SMILESCc1ccc(S\N=C\c2c(O)ccc3ccccc23)cc1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Funamizu N, et al. Tetrahydrouridine inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels. PLoS One. 2012;7(5):e37424.
molnova catalog
related products
-
1-O-Feruloylglucose
The herbs of Catalpa fargesii f. duclouxii.
-
Thiopental sodium
Thiopental sodium (DEA controlled substance) is administered intravenously for the production of complete anesthesia of short duration or for the induction of general anesthesia. It is also used for the control of convulsive states and for hypnosis. It has been used to reduce increased intracranial pressure.
-
Bisacodyl
Bisacodyl (INN) is a stimulant laxative drug that works directly on the colon to produce a bowel movement.
