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COH34
CAS No. 906439-72-3
COH34( -[(E)-(4-methylphenyl)sulfanyliminomethyl]naphthalen-2-ol )
Catalog No. M26126 CAS No. 906439-72-3
COH34 is a selective inhibitor of PARG with an IC50 of 0.37 nM and a Kd of 0.547 μM. COH34 prolongs PARylation at DNA lesions and traps DNA repair factors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 260 | Get Quote |
|
| 10MG | 410 | Get Quote |
|
| 25MG | 678 | Get Quote |
|
| 50MG | 954 | Get Quote |
|
| 100MG | 1287 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameCOH34
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NoteResearch use only, not for human use.
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Brief DescriptionCOH34 is a selective inhibitor of PARG with an IC50 of 0.37 nM and a Kd of 0.547 μM. COH34 prolongs PARylation at DNA lesions and traps DNA repair factors.
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DescriptionCOH34 is a selective inhibitor of PARG with an IC50 of 0.37 nM and a Kd of 0.547 μM. COH34 prolongs PARylation at DNA lesions and traps DNA repair factors.(In Vitro):COH34 potently inhibits PARP inhibitor-resistant cancer cells.(In Vivo):COH34 shows antitumor activity in xenograft mouse cancer models.
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In VitroCOH34 efficiently kills PARP inhibitor-resistant cancer cells.
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In VivoCOH34 induces lethality in cancer cells with DNA repair defects and exhibits antitumor activity in xenograft mouse cancer models.
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Synonyms-[(E)-(4-methylphenyl)sulfanyliminomethyl]naphthalen-2-ol
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PathwayOthers
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TargetOther Targets
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RecptorCytidine deaminase
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Research Area——
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Indication——
Chemical Information
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CAS Number906439-72-3
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Formula Weight293.38
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Molecular FormulaC18H15NOS
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 16.67 mg/mL (56.82 mM)
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SMILESCc1ccc(S\N=C\c2c(O)ccc3ccccc23)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Funamizu N, et al. Tetrahydrouridine inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels. PLoS One. 2012;7(5):e37424.
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