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Chymase-IN-1
CAS No. 862090-74-2
Chymase-IN-1( —— )
Catalog No. M26114 CAS No. 862090-74-2
Chymase-IN-1 is a selective, orally active inhibitor of human mast cell chymase (IC50: 29 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 405 | In Stock |
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| 5MG | 369 | In Stock |
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| 10MG | 525 | In Stock |
|
| 25MG | 787 | In Stock |
|
| 50MG | 1032 | In Stock |
|
| 100MG | 1386 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 2744 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameChymase-IN-1
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NoteResearch use only, not for human use.
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Brief DescriptionChymase-IN-1 is a selective, orally active inhibitor of human mast cell chymase (IC50: 29 nM).
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DescriptionChymase-IN-1 is a selective, orally active inhibitor of human mast cell chymase (IC50: 29 nM).(In Vitro):Chymase-IN-1 (compound 5f) has a chymase Ki value of 36 nM and a Cat G Ki value of 9500 nM.(In Vivo):Chymase-IN-1 shows low oral bioavailability in rats (F=3%; oral t1/2=1.8 h).
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In VitroChymase-IN-1 (compound 5f) is a potent, selective, orally active, nonpeptide inhibitor of human mast cell chymase with an IC50 of 29 nM. Results demonstrate that Chymase-IN-1 has a chymase Ki value of 36 nM and a Cat G Ki value of 9500 nM.
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In VivoChymase-IN-1 exhibits low oral bioavailability in rats (F=3%; oral t1/2=1.8 h).
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorAkt| Angiotensin Receptor| PI3K| β-adrenoceptor
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Research Area——
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Indication——
Chemical Information
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CAS Number862090-74-2
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Formula Weight431.83
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Molecular FormulaC20H15ClNO4PS
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Purity>98% (HPLC)
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Solubility——
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SMILESOP(O)(=O)C(C(=O)Nc1ccc2ccccc2c1)c1csc2ccc(Cl)cc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Sun JJ, Kim HJ, Seo HG, et al. YS49,1-(alpha-naphtylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline,regulates angiotensin II-stimulated ROS production, JNK phosphorylation and vascular smooth muscle cell proliferation via the induction of heme oxygenase-1. Life Sci. 2008;82(11-12):600-7.
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