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Chymase-IN-1

CAS No. 862090-74-2

Chymase-IN-1( —— )

Catalog No. M26114 CAS No. 862090-74-2

Chymase-IN-1 is a selective, orally active inhibitor of human mast cell chymase (IC50: 29 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Chymase-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    Chymase-IN-1 is a selective, orally active inhibitor of human mast cell chymase (IC50: 29 nM).
  • Description
    Chymase-IN-1 is a selective, orally active inhibitor of human mast cell chymase (IC50: 29 nM).(In Vitro):Chymase-IN-1 (compound 5f) has a chymase Ki value of 36 nM and a Cat G Ki value of 9500 nM.(In Vivo):Chymase-IN-1 shows low oral bioavailability in rats (F=3%; oral t1/2=1.8 h).
  • In Vitro
    Chymase-IN-1 (compound 5f) is a potent, selective, orally active, nonpeptide inhibitor of human mast cell chymase with an IC50 of 29 nM. Results demonstrate that Chymase-IN-1 has a chymase Ki value of 36 nM and a Cat G Ki value of 9500 nM.
  • In Vivo
    Chymase-IN-1 exhibits low oral bioavailability in rats (F=3%; oral t1/2=1.8 h).
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Akt| Angiotensin Receptor| PI3K| β-adrenoceptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    862090-74-2
  • Formula Weight
    431.83
  • Molecular Formula
    C20H15ClNO4PS
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    OP(O)(=O)C(C(=O)Nc1ccc2ccccc2c1)c1csc2ccc(Cl)cc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Sun JJ, Kim HJ, Seo HG, et al. YS49,1-(alpha-naphtylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline,regulates angiotensin II-stimulated ROS production, JNK phosphorylation and vascular smooth muscle cell proliferation via the induction of heme oxygenase-1. Life Sci. 2008;82(11-12):600-7.
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