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CHK1-IN-3
CAS No. 2097252-39-4
CHK1-IN-3( —— )
Catalog No. M26107 CAS No. 2097252-39-4
CHK1-IN-2 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 446 | In Stock |
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| 2MG | 244 | In Stock |
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| 5MG | 392 | In Stock |
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| 10MG | 590 | In Stock |
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| 25MG | 917 | In Stock |
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| 50MG | 1190 | In Stock |
|
| 100MG | 1628 | In Stock |
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| 200MG | 2195 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCHK1-IN-3
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NoteResearch use only, not for human use.
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Brief DescriptionCHK1-IN-2 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM).
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DescriptionCHK1-IN-2 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM).(In Vitro):CHK1-IN-3 displays a low affinity for hERG (IC50 > 40 μM). CHK1-IN-3 effectively inhibits the growth of malignant hematopathy cell lines especially Z-138 (IC50: 0.013 μM).(In Vivo):In the Z-138 cell inoculated xenograft model, CHK1-IN-3 significantly suppresses the tumor growth as a single agent with bodyweight unaffected.
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In VitroCHK1-IN-3 effectively inhibites the growth of malignant hematopathy cell lines especially Z-138 (IC50: 0.013 μM) and displays low affinity for hERG (IC50 > 40 μM).
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In VivoCHK1-IN-3 significantly suppresses the tumor growth in Z-138 cell inoculated xenograft model as a single agent with body weight unaffected.
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Synonyms——
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PathwayAngiogenesis
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TargetChk
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RecptorAlkyl-Chain
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Research Area——
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Indication——
Chemical Information
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CAS Number2097252-39-4
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Formula Weight405.466
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Molecular FormulaC20H23N9O
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Purity>98% (HPLC)
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Solubility——
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SMILESCNc1nc(Nc2cnc(C#N)c(O[C@@H]3CCCNC3)c2)ncc1-c1cnn(C)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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MARPIN
MARPIN is a novel ATR-Chk1 pathway inhibitor that inhibits hydroxyurea (HU)-induced phosphorylation of Ser345 on Chk1 with IC50 of 7.7 uM.
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SAR-020106
SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme.SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC(50) of 13.3 nmol/L on the isolated human enzyme. This compound abrogates an etoposide-induced G(2) arrest with an IC(50) of 55 nmol/L in HT29 cells, and significantly enhances the cell killing of gemcitabine and SN38 by 3.0- to 29-fold in several colon tumor lines in vitro and in a p53-dependent fashion.
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Prexasertib dihydroc...
A potent, selective, ATP-competitive inhibitor of CHK1 with Ki of 0.9 nM.
