1-Methylxanthine( —— )

Catalog No. M26013 CAS No. 6136-37-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

1-Methylxanthine
Note

Research use only, not for human use.
Brief Description

1-Methylxanthine is a caffeine derivative. 1-Methylxanthine is an essential human urinary metabolite of caffeine and theophylline (1,3-dimethylxanthine, TP).
Description

1-Methylxanthine is a caffeine derivative. 1-Methylxanthine is an essential human urinary metabolite of caffeine and theophylline (1,3-dimethylxanthine, TP). 1-Methylxanthine enhances the radiosensitivity of tumor cells.(In Vitro):1-Methylxanthine exhibits similar activities to other naturally occurring methylxanthines. Unlike caffeine and theobromine, 3-Methylxanthine, and 1-methylxanthine do not occur naturally at high levels in plants. 1-Methylxanthine (3 mM; for 30 min) increases the radiation-induced clonogenic and apoptotic cell (RKO human colorectal cancer cells carrying wild type protein 53 kDa (p53)) death.
In Vitro

1-Methylxanthine (1-MTX; 3 mM; for 30 min) increases the radiation-induced clonogenic and apoptotic cell (RKO human colorectal cancer cells carrying wild type protein 53 kDa (p53)) death.1-Methylxanthine (1MX) exhibits similar activities to other naturally occurring methylxanthines. Unlike caffeine, TP, and theobromine, 3-Methylxanthine (3MX) and 1-methylxanthine do not occur naturally at high levels in plants.
In Vivo

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Synonyms

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Pathway

Proteasome/Ubiquitin
Target

Endogenous Metabolite
Recptor

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Research Area

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Indication

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1.Marks KR, et al. Synthesis and evaluation of 1-cyclopropyl-2-thioalkyl-8-methoxy fluoroquinolones.Bioorg Med Chem Lett. 2011 Aug 1;21(15):4585-8.

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