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Mefloquine
CAS No. 53230-10-7
Mefloquine( Lariam | Ro 215998 | Ro-215998 | Ro215998 | WR 142490 )
Catalog No. M26006 CAS No. 53230-10-7
Mefloquine, a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 155 | In Stock |
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| 5MG | 148 | In Stock |
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| 10MG | 225 | In Stock |
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| 25MG | 376 | In Stock |
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| 50MG | 527 | In Stock |
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| 100MG | 739 | In Stock |
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| 200MG | 995 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameMefloquine
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NoteResearch use only, not for human use.
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Brief DescriptionMefloquine, a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor.
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DescriptionMefloquine, a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor. Mefloquine is also a K+ channel (KvQT1/minK) antagonist with an IC50 of ~1 μM. Mefloquine can be used for malaria, systemic lupus erythematosus, and cancer research.
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In VitroMefloquine selectively inhibits prostate cancer (PCa) cell growth with an IC50 of ~10 μM. Mefloquine also induces hyperpolarization of the mitochondrial membrane potential (MMP), as well as ROS generation.Mefloquine (10 μM)-mediated ROS simultaneously downregulated Akt phosphorylation and activated ERK, JNK and AMPK signaling in PC3 cells.Mefloquine shows higher anti-SARS-CoV-2 activity than Hydroxychloroquine in VeroE6/TMPRSS2 and Calu-3 cells, with IC50 of 1.28 μM, IC90 of 2.31 μM, and IC99 of 4.39 μM in VeroE6/TMPRSS2 cells. Mefloquine inhibits viral entry after viral attachment to the target cell.
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In VivoMefloquine (5 mg/kg; i.p.; daily; 14 days) reverses the lower vertebral cancellous bone volume and bone formation; and has modest effects on cortical bone volume, thickness, and moment of inertia in old mice.
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SynonymsLariam | Ro 215998 | Ro-215998 | Ro215998 | WR 142490
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PathwayOthers
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TargetOther Targets
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RecptorBacterial
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Research Area——
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Indication——
Chemical Information
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CAS Number53230-10-7
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Formula Weight378.318
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Molecular FormulaC17H16F6N2O
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Purity>98% (HPLC)
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Solubility——
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SMILESO[C@H]([C@H]1CCCCN1)c1cc(nc2c(cccc12)C(F)(F)F)C(F)(F)F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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2-Oxo-3-phenylpropan...
Phenylpyruvic acid is a keto-acid that is an intermediate or catabolic byproduct of phenylalanine metabolism. It has a slight honey-like odor. Levels of phenylpyruvate are normally very low in blood or urine. High levels of phenylpyruvic acid can be found in the urine of individuals with phenylketonuria (PKU) an inborn error of metabolism.
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GSK2807 Trifluoroace...
GSK2807 Trifluoroacetate is a selective and SAM-competitive inhibitor of SMYD3 (Ki: 14 nM; IC50: 130 nM).GSK2807, a potent and selective, SAM-competitive inhibitor of SMYD3 (Ki = 14 nM).?A high-resolution crystal structure reveals that GSK2807 bridges the gap between the SAM-binding pocket and the substrate lysine tunnel of SMYD3.
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Bis(4-nitrophenyl) p...
Bis(4-nitrophenyl) phosphate (BNPP) inhibits UDP-galactose and can be used to study glycosyltransferase membrane topology.
