Cart
sales@molnova.com
GS-143
CAS No. 916232-21-8
GS-143( GS 143 | GS143 )
Catalog No. M24964 CAS No. 916232-21-8
GS143 is a selec-tive IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 52 | In Stock |
|
| 2MG | 30 | In Stock |
|
| 5MG | 50 | In Stock |
|
| 10MG | 80 | In Stock |
|
| 25MG | 164 | In Stock |
|
| 50MG | 254 | In Stock |
|
| 100MG | 369 | In Stock |
|
| 200MG | 537 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameGS-143
-
NoteResearch use only, not for human use.
-
Brief DescriptionGS143 is a selec-tive IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation.
-
DescriptionGS143 is a selec-tive IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 sup-presses NF-κB acti-va-tion and tran-scrip-tion of tar-get genes and does not inhibit proteasome activity. GS143 has anti-asthma effect.
-
In Vitro——
-
In VivoAnimal Model:BALB/c mice (age 7-8weeks) injected with oval-bu-min Dosage:16 μg/body or 32 μg/body Administration:Intranasal administration; once Result:Suppressed antigen-induced NF-κB activation in the lung of sensitized mice.
-
SynonymsGS 143 | GS143
-
PathwayOthers
-
TargetOther Targets
-
RecptorIκBα?phosphorylation
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number916232-21-8
-
Formula Weight466.46
-
Molecular FormulaC28H19FN2O4
-
Purity>98% (HPLC)
-
SolubilityDMSO:40 mg/mL?(85.75 mM;?Need ultrasonic)
-
SMILESOC(c(cc1)ccc1N(C1=O)N=C(Cc2ccccc2)C1=Cc1ccc(-c(cccc2)c2F)o1)=O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Rashmi BS, Gayathri D. Molecular characterization of gluten hydrolysing Bacillus sp. and their efficacy and biotherapeutic potential as probiotics using Caco-2 cell line. J Appl Microbiol. 2017 Sep;123(3):759-772. doi: 10.1111/jam.13517. Epub 2017 Aug 4. PubMed PMID: 28637081.
molnova catalog
related products
-
Nardoaristolone B
Nardoaristolone B, a nor-sesquiterpenoid with an unusual fused ring system and having protective effects on the injury of neonatal rat cardiomyocytes.
-
3-(3-Hydroxyphenyl)p...
3-(3-Hydroxyphenyl)propionic Acid is one of the major metabolites of ingested caffeic acid.it?inhibited osteoclastogenesis and bone osteoclastic resorptive activity.
-
Oxyphyllacinol
Oxyphyllacinol has antidiarrheal activity.Oxyphyllacinol has been shown to treat dementia. Oxyphyllacinol was isolated from the S. nodiflora water fraction, while the S. nodiflora water fraction has been shown to have antioxidant and anti-aging activities, inducing mitochondrial activity and increasing ctt1 gene expression by regulating stress tolerance response.
