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Fosravuconazole L-lysine ethanolate

CAS No. 914361-45-8

Fosravuconazole L-lysine ethanolate( BMS-379224 L-lysine ethanolate | E-1224 L-lysine ethanolate )

Catalog No. M24954 CAS No. 914361-45-8

FosravuconazoleL-lysine ethanolate is a broad-spectrum antifungal agent. In Japan, it is approved for the treatment of onychomycosis, a fungal infection of the nail. It is a prodrug that is converted into ravuconazole.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Fosravuconazole L-lysine ethanolate
  • Note
    Research use only, not for human use.
  • Brief Description
    FosravuconazoleL-lysine ethanolate is a broad-spectrum antifungal agent. In Japan, it is approved for the treatment of onychomycosis, a fungal infection of the nail. It is a prodrug that is converted into ravuconazole.
  • Description
    FosravuconazoleL-lysine ethanolate is a broad-spectrum antifungal agent. In Japan, it is approved for the treatment of onychomycosis, a fungal infection of the nail. It is a prodrug that is converted into ravuconazole.(In Vitro):Fosravuconazole has potent in vitro antifungal activity against a wide range of fungal species, including Candida, Aspergillus, and Trichophyton species.(In Vivo):Fosravuconazole (E-1224; 10-50 mg/kg; oral administration; daily; for 20 days) treatment suppresses the parasitemia and prevents death in mice infected with the T. cruzi Y strain.
  • In Vitro
    Fosravuconazole has potent in vitro antifungal activity against a wide range of fungal species, including Candida, Aspergillus, and Trichophyton species.
  • In Vivo
    Fosravuconazole (E-1224; 10-50 mg/kg; oral administration; daily; for 20 days) treatment suppresses the parasitemia and prevents death in mice infected with the T. cruzi Y strain. Animal Model:Swiss female mice (20-24 g) inoculated with trypomastigotes (Y strain).Dosage:10 mg/kg, 20 mg/kg, 30 mg/kg, 40 mg/kg, 50 mg/kg Administration:Oral administration; daily; for 20 days Result:Suppressed the parasitemia and prevented death.
  • Synonyms
    BMS-379224 L-lysine ethanolate | E-1224 L-lysine ethanolate
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    914361-45-8
  • Formula Weight
    739.7
  • Molecular Formula
    C31H40F2N7O8PS
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:48mg/mL (64.89mM)
  • SMILES
    N#CC1=CC=C(C2=CSC([C@H](C)[C@@](OCOP(O)(O)=O)(C3=CC=C(F)C=C3F)CN4N=CN=C4)=N2)C=C1.CCO.N[C@H](C(O)=O)CCCCN
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Diniz LF, Mazzeti AL, Caldas IS, Ribeiro I, Bahia MT. Outcome of E1224-Benznidazole Combination Treatment for Infection with a Multidrug-Resistant Trypanosoma cruzi Strain in Mice. Antimicrob Agents Chemother. 2018;62(6):e00401-18. Published 2018 May 25. doi:10.1128/AAC.00401-18Watanabe S, Tsubouchi I, Okubo A. Efficacy and safety of fosravuconazole L-lysine ethanolate, a novel oral triazole antifungal agent, for the treatment of onychomycosis: A multicenter, double-blind, randomized phase III study. J Dermatol. 2018;45(10):1151-1159. doi:10.1111/1346-8138.14607
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