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SEC inhibitor KL-1

CAS No. 900308-84-1

SEC inhibitor KL-1( KL-1 )

Catalog No. M24926 CAS No. 900308-84-1

SEC inhibitor KL-1 exhibits a dose-dependent inhibitory effect on AFF4-CCNT1 interaction (Ki: 3.48 μM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 87 In Stock
2MG 48 In Stock
5MG 79 In Stock
10MG 126 In Stock
25MG 216 In Stock
50MG 319 In Stock
100MG 454 In Stock
200MG 631 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    SEC inhibitor KL-1
  • Note
    Research use only, not for human use.
  • Brief Description
    SEC inhibitor KL-1 exhibits a dose-dependent inhibitory effect on AFF4-CCNT1 interaction (Ki: 3.48 μM).
  • Description
    SEC inhibitor KL-1 exhibits a dose-dependent inhibitory effect on AFF4-CCNT1 interaction (Ki: 3.48 μM). SEC inhibitor KL-1 is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    KL-1
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    SEC
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    900308-84-1
  • Formula Weight
    345.78
  • Molecular Formula
    C18H16ClNO4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:41.67 mg/mL (120.51 mM; Need ultrasonic)
  • SMILES
    CC1=C(C=C(C=C1)Cl)NC(=O)C(=O)CC(=O)C2=CC(=CC=C2)OC
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Liang K, et al. Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced CancerTherapy. Cell. 2018 Oct 18;175(3):766-779.
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