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XL228
CAS No. 898280-07-4
XL228( —— )
Catalog No. M24922 CAS No. 898280-07-4
XL228 is an inhibitor of multi-targeted tyrosine kinase.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 106 | In Stock |
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| 2MG | 67 | In Stock |
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| 5MG | 96 | In Stock |
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| 10MG | 144 | In Stock |
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| 25MG | 257 | In Stock |
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| 50MG | 384 | In Stock |
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| 100MG | 570 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameXL228
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NoteResearch use only, not for human use.
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Brief DescriptionXL228 is an inhibitor of multi-targeted tyrosine kinase.
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DescriptionXL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetBcr-Abl
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RecptorAurora A|Bcr-Abl|IGF-1R|Lyn|Src
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Research Area——
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Indication——
Chemical Information
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CAS Number898280-07-4
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Formula Weight437.54
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Molecular FormulaC22H31N9O
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Purity>98% (HPLC)
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SolubilityDMSO:83.33 mg/mL (190.45 mM)
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SMILESCC(C)c1noc(CNc2nc(N3CCN(C)CC3)cc(Nc3n[nH]c(C4CC4)c3)n2)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Cortes J, et al. Preliminary Clinical Activity in a Phase I Trial of the BCR-ABL/IGF- 1R/Aurora Kinase Inhibitor XL228 in Patients with Ph++ Leukemias with Either Failure to Multiple TKI Therapies or with T315I Mutation. Blood 2008 112:3232
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