NY2267
CAS No. 886053-73-2
NY2267( Acetic acid, 2-[[6-[2-(cyclohexylamino)-1-[[(4-methoxyphenyl)methyl](2-pyridinylcarbonyl)amino]-2-oxoethyl]-2-naphthalenyl]oxy]-, 1,1-dimethylethyl ester )
Catalog No. M24905 CAS No. 886053-73-2
NY2267 is a disruptor of Myc-Max interaction, with an IC50 of 36.5 μM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 222 | In Stock |
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| 10MG | 357 | In Stock |
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| 25MG | 597 | In Stock |
|
| 50MG | 851 | In Stock |
|
| 100MG | 1152 | In Stock |
|
| 500MG | 2313 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNY2267
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NoteResearch use only, not for human use.
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Brief DescriptionNY2267 is a disruptor of Myc-Max interaction, with an IC50 of 36.5 μM.
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DescriptionNY2267 is a disruptor of Myc-Max interaction, with an IC50 of 36.5 μM.
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In Vitro——
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In Vivo——
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SynonymsAcetic acid, 2-[[6-[2-(cyclohexylamino)-1-[[(4-methoxyphenyl)methyl](2-pyridinylcarbonyl)amino]-2-oxoethyl]-2-naphthalenyl]oxy]-, 1,1-dimethylethyl ester
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PathwayCell Cycle/DNA Damage
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Targetc-Myc
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Recptorc-Myc-Max
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Research Area——
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Indication——
Chemical Information
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CAS Number886053-73-2
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Formula Weight637.78
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Molecular FormulaC38H43N3O6
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Purity>98% (HPLC)
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SolubilityDMSO : 250 mg/mL (392.00 mM; Need ultrasonic and warming)
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SMILESO=C(OC(C)(C)C)COC1=CC=C2C=C(C(N(CC3=CC=C(OC)C=C3)C(C4=NC=CC=C4)=O)C(NC5CCCCC5)=O)C=CC2=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Stauprimide
A staurosporine analog that promotes embryonic stem cell (ESC) differentiation by inhibiting nuclear localization of the MYC transcription factor NME2.
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MYCi975
MYCi975 is an orally active inhibitor of MYC.MYCi975 inhibits P493-6, MV411,SK-N-B2 cells viability in an MYC-dependent manner(IC50s of 3.7, 3.9, 6.4 μM, respectively).The initial lead, MYC inhibitor 361 (MYCi361), suppressed in vivo tumor growth in mice, increased tumor immune cell infiltration, upregulated PD-L1 on tumors, and sensitized tumors to anti-PD1 immunotherapy. However, 361 demonstrated a narrow therapeutic index.
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APTO-253
APTO-253 inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells. APTO-253 mediates anticancer activity through the induction of the KLF4 tumor suppressor.APTO-253 (5 μM) induces KLF4 expression and enhances apoptosis induced by NSC 119875 in both SKOV3 and OVCAR3 cells.
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