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SEN 12333
CAS No. 874450-44-9
SEN 12333( —— )
Catalog No. M24888 CAS No. 874450-44-9
α7 nicotinic acetylcholine receptor (nAChR) agonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 54 | In Stock |
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| 2MG | 31 | In Stock |
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| 5MG | 49 | In Stock |
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| 10MG | 83 | In Stock |
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| 25MG | 167 | In Stock |
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| 50MG | 263 | In Stock |
|
| 100MG | 423 | In Stock |
|
| 200MG | 609 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSEN 12333
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NoteResearch use only, not for human use.
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Brief Descriptionα7 nicotinic acetylcholine receptor (nAChR) agonist.
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Descriptionα7 nicotinic acetylcholine receptor (nAChR) agonist.
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In VitroIn whole-cell patch-clamp recordings, SEN12333 activates peak currents and maximal total charges similar to acetylcholine (EC50= 12 μM). SEN12333 displays functional antagonism at histamine H3?receptors (IC50=103 nM) and weak agonist activity at human ganglionic?α3 nAChRs (IC50=8.5?μM).
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In VivoSEN12333 (intraperitoneal?injection; 3 mg/kg) improves episodic memory in a novel object recognition task in rats in conditions of spontaneous forgetting as well as cognitive disruptions induced via glutamatergic or cholinergic mechanisms. SEN12333 also prevents a scopolamine-induced deficit in a passive avoidance task.
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Synonyms——
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PathwayEndocrinology/Hormones
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TargetAChR
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Recptorα7 nAChR
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Research Area——
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Indication——
Chemical Information
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CAS Number874450-44-9
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Formula Weight339.43
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Molecular FormulaC20H25N3O2
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Purity>98% (HPLC)
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SolubilityDMSO:<33.94mg/ml
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SMILESO=C(CCCCN1CCOCC1)Nc(cc1)ccc1-c1cnccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog
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