PRX-08066( —— )

Catalog No. M24869 CAS No. 866206-54-4

PRX-08066 is a selective 5-hydroxytryptamine receptor 2B (5-HT2BR, IC50= 3.4 nM) antagonist that induces selective vasodilation of pulmonary arteries.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
5MG	110	In Stock
10MG	160	In Stock
25MG	332	In Stock
50MG	494	In Stock
100MG	709	In Stock
500MG	1467	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

PRX-08066
Note

Research use only, not for human use.
Brief Description

PRX-08066 is a selective 5-hydroxytryptamine receptor 2B (5-HT2BR, IC50= 3.4 nM) antagonist that induces selective vasodilation of pulmonary arteries.
Description

PRX-08066 is a selective 5-hydroxytryptamine receptor 2B (5-HT2BR, IC50= 3.4 nM) antagonist that induces selective vasodilation of pulmonary arteries.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Endocrinology/Hormones
Target

5-HT Receptor
Recptor

5-HT2B
Research Area

——
Indication

——

Chemical Information

CAS Number

866206-54-4
Formula Weight

401.89
Molecular Formula

C19H17ClFN5S
Purity

>98% (HPLC)
Solubility

DMSO:7 mg/mL (17.42 mM; Need ultrasonic)
SMILES

C1CN(CCC1NC2=C3C=C(SC3=NC=N2)Cl)CC4=CC(=C(C=C4)F)C#N
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Porvasnik SL, et al. PRX-08066, a novel 5-hydroxytryptamine receptor 2B antagonist, reduces monocrotaline-induced pulmonary arterial hypertension and right ventricular hypertrophy in rats. J Pharmacol Exp Ther. 2010 Aug;334(2):364-72.

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