Tauro-Obeticholic acid( —— )

Catalog No. M24862 CAS No. 863239-61-6

COA

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HPLC

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Product Name

Tauro-Obeticholic acid
Note

Research use only, not for human use.
Brief Description

Tauro-Obeticholic acid is an active Obeticholic acid metabolite. Obeticholic acid is an orally bioavailable agonist of farnesoid-X receptor (FXR).
Description

Tauro-Obeticholic acid is an active Obeticholic acid metabolite. Obeticholic acid is an orally bioavailable agonist of farnesoid-X receptor (FXR).
In Vitro

Obeticholic acid is conjugated with taurine in the liver to form Tauro-obeticholic acid, which is secreted into bile. Microorganisms in the ileum and colon can deconjugate Tauro-obeticholic acid, converting it into the parent drug, which may then be reabsorbed or excreted in faeces.
In Vivo

——
Synonyms

——
Pathway

Metabolic Enzyme/Protease
Target

FXR
Recptor

FXR
Research Area

——
Indication

——

CAS Number

863239-61-6
Formula Weight

527.76
Molecular Formula

C28H49NO6S
Purity

>98% (HPLC)
Solubility

——
SMILES

C[C@H](CCC(NCCS(=O)(O)=O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])[C@H](O)[C@H](CC)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
Chemical Name

——

1.Markham A, et al. Obeticholic Acid: First Global Approval. Drugs. 2016 Aug;76(12):1221-6.

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