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DM4
CAS No. 796073-69-3
DM4( Ravtansine )
Catalog No. M24795 CAS No. 796073-69-3
DM4 can be used in the preparation of antibody drug conjugate and it is an antitubulin agent. It can inhibit cell division.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 109 | In Stock |
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| 2MG | 42 | In Stock |
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| 5MG | 68 | In Stock |
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| 10MG | 126 | In Stock |
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| 25MG | 242 | In Stock |
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| 50MG | 417 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameDM4
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NoteResearch use only, not for human use.
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Brief DescriptionDM4 can be used in the preparation of antibody drug conjugate and it is an antitubulin agent. It can inhibit cell division.
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DescriptionDM4 can be used in the preparation of antibody drug conjugate and it is an antitubulin agent. It can inhibit cell division.
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In VitroDM4, a structural analogue of maytansine, is a new thiol-containing and potent maytansinoid. DM4 is a cytotoxic maytansinoid drug. It is synthesized in order to link maytansinoids to antibodies via disulfide bonds. Maytansinoids inhibit tubulin polymerization and microtubule assembly and enhance microtubule destabilization, so there is potent suppression of microtubule dynamics resulting in a mitotic block and subsequent apoptotic cell death.
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In Vivo——
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SynonymsRavtansine
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number796073-69-3
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Formula Weight780.37
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Molecular FormulaC38H54ClN3O10S
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Purity>98% (HPLC)
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SolubilityDMSO: 99 mg/mL (126.86 mM; Need ultrasonic)
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SMILESCO[C@@H]1/C=C/C=C(Cc2cc(N(C(C[C@@H]([C@@]3(O[C@H]3[C@@H]([C@@H]4C[C@]1(NC(O4)=O)O)C)C)OC([C@@H](N(C(CCC(C)(S)C)=O)C)C)=O)=O)C)c(Cl)c(OC)c2)\C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Tang R, et al. P-gp activity is a critical resistance factor against AVE9633 and DM4 cytotoxicity in leukaemia cell lines, but not a major mechanism of chemoresistance in cells from acute myeloid leukaemia patients. BMC Cancer. 2009 Jun 23;9:199.
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