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GOT1 inhibitor-1
CAS No. 732973-87-4
GOT1 inhibitor-1( GOT1 inhibitor 2c )
Catalog No. M24741 CAS No. 732973-87-4
GOT1 inhibitor-1 is a novel, potent and non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with an IC50 of 8.2 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 215 | In Stock |
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| 5MG | 187 | In Stock |
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| 10MG | 312 | In Stock |
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| 25MG | 530 | In Stock |
|
| 50MG | 733 | In Stock |
|
| 100MG | 1042 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGOT1 inhibitor-1
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NoteResearch use only, not for human use.
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Brief DescriptionGOT1 inhibitor-1 is a novel, potent and non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with an IC50 of 8.2 uM.
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DescriptionGOT1 inhibitor-1 is a novel, potent and non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with an IC50 of 8.2 uM.
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In VitroPDAC tumors are dependent upon a metabolic pathway involving aspartate aminotransferase 1 (glutamate-oxaloacetate transaminase 1 (GOT1)), for the maintenance of redox homeostasis and sustained proliferation. Small molecule inhibitors targeting this metabolic pathway may provide a novel way for cancer research.In the MDH coupled GOT1 enzymatic assay, GOT1 inhibitor-1 shows an inhibitory effect on GOT1 activity with an IC50 value of 8.2 uM.
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In Vivo——
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SynonymsGOT1 inhibitor 2c
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PathwayOthers
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TargetOther Targets
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RecptorGOT1
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Research Area——
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Indication——
Chemical Information
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CAS Number732973-87-4
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Formula Weight354.83
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Molecular FormulaC19H19ClN4O
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Purity>98% (HPLC)
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SolubilityDMSO:120mg/ml(338.19mM; need ultrasonic)
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SMILESO=C(Nc(cc1)ccc1Cl)N(CC1)CCN1c1c(cc[nH]2)c2ccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Anglin J , Zavareh R B , Sander P N , et al. Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma[J]. Bioorganic & Medicinal Chemistry Letters, 2018:S0960894X18303743.
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