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Vercirnon

CAS No. 698394-73-9

Vercirnon( GSK-1605786 | CCX282-B | Traficet-EN )

Catalog No. M24714 CAS No. 698394-73-9

Vercirnon is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 363 In Stock
5MG 258 In Stock
10MG 407 In Stock
25MG 680 In Stock
50MG 918 In Stock
100MG 1274 In Stock
200MG Get Quote In Stock
500MG 2539 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Vercirnon
  • Note
    Research use only, not for human use.
  • Brief Description
    Vercirnon is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases.
  • Description
    Vercirnon is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases.
  • In Vitro
    ——
  • In Vivo
    Animal Model:C57BL/6 mice (TNFΔARE Mouse Model of Terminal Ileitis)Dosage:10, 50 mg/kg Administration:Subcutaneous; twice per day; starting at 2 weeks of age until 12 weeks of age Result:Resulted in complete protection from the severe inflammation associated with TNF- overexpression at 50 mg/kg. A similar protective effect was also noted with a lower dose.
  • Synonyms
    GSK-1605786 | CCX282-B | Traficet-EN
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    CCR9
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    698394-73-9
  • Formula Weight
    444.93
  • Molecular Formula
    C22H21ClN2O4S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 22.25 mg/mL (50 mM)
  • SMILES
    CC(C)(C)c(cc1)ccc1S(Nc(ccc(Cl)c1)c1C(c(cc1)cc[n+]1[O-])=O)(=O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Walters MJ, et al. Characterization of CCX282-B, an orally bioavailable antagonist of the CCR9 chemokine receptor, for treatment of inflammatory bowel disease. J Pharmacol Exp Ther. 2010 Oct;335(1):61-9.
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