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Vercirnon
CAS No. 698394-73-9
Vercirnon( GSK-1605786 | CCX282-B | Traficet-EN )
Catalog No. M24714 CAS No. 698394-73-9
Vercirnon is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 363 | In Stock |
|
| 5MG | 258 | In Stock |
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| 10MG | 407 | In Stock |
|
| 25MG | 680 | In Stock |
|
| 50MG | 918 | In Stock |
|
| 100MG | 1274 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 2539 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameVercirnon
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NoteResearch use only, not for human use.
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Brief DescriptionVercirnon is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases.
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DescriptionVercirnon is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases.
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In Vitro——
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In VivoAnimal Model:C57BL/6 mice (TNFΔARE Mouse Model of Terminal Ileitis)Dosage:10, 50 mg/kg Administration:Subcutaneous; twice per day; starting at 2 weeks of age until 12 weeks of age Result:Resulted in complete protection from the severe inflammation associated with TNF- overexpression at 50 mg/kg. A similar protective effect was also noted with a lower dose.
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SynonymsGSK-1605786 | CCX282-B | Traficet-EN
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PathwayOthers
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TargetOther Targets
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RecptorCCR9
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Research Area——
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Indication——
Chemical Information
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CAS Number698394-73-9
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Formula Weight444.93
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Molecular FormulaC22H21ClN2O4S
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Purity>98% (HPLC)
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SolubilityDMSO : 22.25 mg/mL (50 mM)
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SMILESCC(C)(C)c(cc1)ccc1S(Nc(ccc(Cl)c1)c1C(c(cc1)cc[n+]1[O-])=O)(=O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Walters MJ, et al. Characterization of CCX282-B, an orally bioavailable antagonist of the CCR9 chemokine receptor, for treatment of inflammatory bowel disease. J Pharmacol Exp Ther. 2010 Oct;335(1):61-9.
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