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GSTO1-IN-1
CAS No. 568544-03-6
GSTO1-IN-1( —— )
Catalog No. M24557 CAS No. 568544-03-6
GSTO1-IN-1 is a potent glutathione S-transferase omega 1 inhibitor (GSTO1; IC50: 31 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 62 | In Stock |
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| 2MG | 29 | In Stock |
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| 5MG | 44 | In Stock |
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| 10MG | 69 | In Stock |
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| 25MG | 86 | In Stock |
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| 50MG | 100 | In Stock |
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| 100MG | 175 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 427 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGSTO1-IN-1
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NoteResearch use only, not for human use.
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Brief DescriptionGSTO1-IN-1 is a potent glutathione S-transferase omega 1 inhibitor (GSTO1; IC50: 31 nM).
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DescriptionGSTO1-IN-1 is a potent glutathione S-transferase omega 1 inhibitor (GSTO1; IC50: 31 nM).
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In VitroGSTO1-IN-1 (C1-27) potently inhibits GSTO1 enzyme activity with an IC50 value of 31 nM. GSTO1-IN-1 also potently competes with 5-chloromethylfluorescein diacetate (CMFDA) for binding to recombinant protein, as well as endogenous GSTO1 in the milieu of a soluble proteome. HCT116 cells treated with GSTO1-IN-1 also show a decrease in cell viability in a dose-dependent manner. GSTO1-IN-1 inhibits the clonogenic survival of HCT116 cells at sub-micromolar concentrations.
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In VivoTo test whether GSTO1-IN-1 had in vivo efficacy, its effects are evaluated in a human colon cancer cell line xenograft model. GSTO1-IN-1 (20-45 mg/kg) is administered as a single agent to nude mice bearing HCT116 xenografts. After 5 weeks of treatment, tumor growth is significantly inhibited in GSTO1-IN-1-treated mice compared with the vehicle-treated group (P<0.05). GSTO1-IN-1 treatment is generally well tolerated by mice up to 45 mg/kg, with no overt signs of toxicity and no significant variations in average body weights throughout the duration of the study.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorGSTO1
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Research Area——
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Indication——
Chemical Information
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CAS Number568544-03-6
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Formula Weight311.18
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Molecular FormulaC10H12Cl2N2O3S
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Purity>98% (HPLC)
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SolubilityDMSO:300 mg/mL (964.07 mM)
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SMILESCN(C)S(c(cc(cc1)NC(CCl)=O)c1Cl)(=O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Ramkumar K, et al. Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor. Nat Commun. 2016 Oct 5;7:13084.
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