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IMD-0560
CAS No. 439144-66-8
IMD-0560( —— )
Catalog No. M24398 CAS No. 439144-66-8
IMD-0560 is a novel inhibitor of IκB kinase β.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 84 | In Stock |
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| 10MG | 135 | In Stock |
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| 25MG | 244 | In Stock |
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| 50MG | 359 | In Stock |
|
| 100MG | 493 | In Stock |
|
| 200MG | 678 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameIMD-0560
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NoteResearch use only, not for human use.
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Brief DescriptionIMD-0560 is a novel inhibitor of IκB kinase β.
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DescriptionIMD-0560 is a novel inhibitor of IκB kinase β.
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In VitroPretreatment with IMD-0560 inhibits both IκBα degradation and p65 phosphorylation induced by TNFα. IMD-0560 also suppresses TNFα-induced transcriptional activity. Pretreatment with IMD-0560 strongly inhibits TNFα-induced cell invasion. Pretreatment with IMD-0560 suppresses MMP-9 activity by inhibiting MMP-9 expression.
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In VivoThe tumor size is reduced in the IMD-0560-treated groups in a dose-dependent manner, and no tumor is detected in some mice treated with 5 mg/kg IMD-0560.Zygoma destruction is significantly suppressed in the IMD-0560-treated groups compare to the control groups. Although the tumor size in the 5 mg/kg IMD-0560-treated group is smaller than that of the 3 mg/kg IMD-0560-treated group, the inhibitory effect of each treatment on zygoma destruction is similar.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorIKKβ
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Research Area——
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Indication——
Chemical Information
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CAS Number439144-66-8
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Formula Weight428.12
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Molecular FormulaC15H8BrF6NO2
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Purity>98% (HPLC)
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SolubilityEthanol:50 mg/mL (116.79 mM; Need ultrasonic)
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SMILESO=C(NC1=CC(C(F)(F)F)=CC=C1C(F)(F)F)C2=CC(Br)=CC=C2O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Tada Y, et al. The novel IκB kinase β inhibitor IMD-0560 prevents bone invasion by oral squamous cell carcinoma. Oncotarget. 2014 Dec 15;5(23):12317-30.
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