Polyinosinic-polycytidylic acid sodium

Research use only, not for human use.

Polyinosinic-polycytidylic acid sodium is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5).

Polyinosinic-polycytidylic acid sodium is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5).

Cell Viability Assay Cell Line:WM793, WM278, WM239A, WM9 and 1205Lu cells Concentration:20 ng/mL Incubation Time:24 hoursResult:Strongly reduced viability from 100% in controls to 20%–50% within 24 hours.Apoptosis Analysis Cell Line:1205Lu cells Concentration:200 ng/mL Incubation Time:24 hours Result:Induced apoptosis in 1205Lu cells.RT-PCR Cell Line:1205Lu cells Concentration:3 ng/mL Incubation Time:24 hours Result:Induced IFN-β expression in melanoma cells.Western Blot Analysis Cell Line:1205Lu cells Concentration:5 ng/mL Incubation Time:24 hours Result:Revealed active subunits of caspase-9 and caspase-8 in melanoma cells.

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Poly(I:C) sodium

Immunology/Inflammation

TLR

TLR3|RIG-I|MDA5|apoptosis

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42424-50-0

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(C10H13N4O8P)x.(C9H14N3O8P)x.xNa

>98% (HPLC)

H2O:10 mg/mL?(Need ultrasonic and warming)

C1=CN(C(=O)N=C1N)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)O)O)O.C1=NC2=C(C(=O)N1)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)O)O)O.[Na]

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(-20℃)

With Ice Pack

≥ 2 years