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TQS
CAS No. 353483-92-8
TQS( 4-Naphthalen-1-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide )
Catalog No. M24306 CAS No. 353483-92-8
TQS is a positive allosteric modulator of α7 nACh receptors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 32 | In Stock |
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| 5MG | 30 | In Stock |
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| 10MG | 48 | In Stock |
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| 25MG | 105 | In Stock |
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| 50MG | 166 | In Stock |
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| 100MG | 245 | In Stock |
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| 200MG | 349 | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTQS
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NoteResearch use only, not for human use.
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Brief DescriptionTQS is a positive allosteric modulator of α7 nACh receptors.
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DescriptionTQS is a positive allosteric modulator of α7 nACh receptors.
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In Vitro——
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In VivoTQS (1 or 4 mg/kg; i.p.) reduces the expression of LPS-induced IκB mRNA, CD11b mRNA and regulates microglial morphological changes in the hippocampus. Animal Model:Male C57BL/6J miceDosage:1 or 4 mg/kg Administration:I.p.Result:Reduced the expression of LPS-induced IκB mRNA, CD11b mRNA and regulated microglial morphological changes in the hippocampus.
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Synonyms4-Naphthalen-1-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide
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PathwayEndocrinology/Hormones
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TargetAChR
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Recptorα7 nAChR
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Research Area——
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Indication——
Chemical Information
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CAS Number353483-92-8
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Formula Weight376.47
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Molecular FormulaC22H20N2O2S
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Purity>98% (HPLC)
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SolubilityDMSO : 240 mg/mL?(637.50 mM;?Need ultrasonic)
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SMILESNS(c(cc1)cc(C2C=CCC22)c1NC2c1cccc2ccccc12)(=O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Muzaffar A , Sami A , Papke R L , et al. The α7 nicotinic acetylcholine receptor positive allosteric modulator attenuates lipopolysaccharide-induced activation of hippocampal IκB and CD11b gene expression in mice[J]. Drug Discoveries & Therapeutics, 2017, 11(4):206-211.
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