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N-(4-Fluorophenyl)-4-phenyl-2-thiazolami

CAS No. 339303-87-6

N-(4-Fluorophenyl)-4-phenyl-2-thiazolami( —— )

Catalog No. M24289 CAS No. 339303-87-6

N-(4-Fluorophenyl)-4-phenyl-2-thiazolami is a potent, brain-penetrant and orally active GP130 receptor agonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 55 In Stock
5MG 39 In Stock
10MG 62 In Stock
25MG 122 In Stock
50MG 221 In Stock
100MG 321 In Stock
200MG 437 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    N-(4-Fluorophenyl)-4-phenyl-2-thiazolami
  • Note
    Research use only, not for human use.
  • Brief Description
    N-(4-Fluorophenyl)-4-phenyl-2-thiazolami is a potent, brain-penetrant and orally active GP130 receptor agonist.
  • Description
    N-(4-Fluorophenyl)-4-phenyl-2-thiazolami is a potent, brain-penetrant and orally active GP130 receptor agonist.
  • In Vitro
    In SH-SY5Y cells, GP130 receptor agonist-1 (Compound 2) treatment showed a 2-fold increase in phosphorylation of STAT3 within 10 min at its regulatory Tyr705 site. In primary hippocampal neuronal cultures, the pSTAT3 levels are below levels of detection for GP130 receptor agonist-1 at all time points.GP130 receptor agonist-1 treatment shows increases phosphorylation of AKT at its regulatory Thr308 site and phosphorylation of ERK1/2 at its regulatory Thr202/Tyr204 site in the serum free media condition in SH-SY5Y cells, andin primary cortical neurons.
  • In Vivo
    For GP130 receptor agonist-1 (Compound 2), mice are dosed orally at 10 or 30 mg/kg, or injected subcutaneously (SQ) at 10 mg/kg, and euthanized after 1, 2, 4, 6, and 8 h post dose. At 2 h after SQ delivery at 10 mg/kg the brain Cmax is 161 ng/g while dosing at 30 mg/kg orally, results in the brain Cmax of 156 ng/g (0.57 μM). The brain to plasma ratio for 2 is ～4:1 for oral 30 mg/kg and ～7.5:1 for 10 mg/kg SQ injection.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    gp130
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    339303-87-6
  • Formula Weight
    270.32
  • Molecular Formula
    C15H11FN2S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (369.93 mM)
  • SMILES
    Fc(cc1)ccc1Nc1nc(-c2ccccc2)cs1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Mohammad Parvez Alam,et al. A Small Molecule Mimetic of the Humanin Peptide as a Candidate for Modulating NMDA-Induced Neurotoxicity. ACS Chem Neurosci. 2018 Mar 21;9(3):462-468.
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