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TS-011

CAS No. 339071-18-0

TS-011( N-(3-Chloro-4-morpholinophenyl)-N'-hydroxyformimidamide )

Catalog No. M24288 CAS No. 339071-18-0

TS-011 is a selective 20-Hydroxyeicosatetraenoic acid synthesis inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    TS-011
  • Note
    Research use only, not for human use.
  • Brief Description
    TS-011 is a selective 20-Hydroxyeicosatetraenoic acid synthesis inhibitor.
  • Description
    TS-011 is a selective 20-Hydroxyeicosatetraenoic acid synthesis inhibitor.
  • In Vitro
    ——
  • In Vivo
    TS-011 is a selective inhibitor of 20-Hydroxyeicosatetraenoic acidsynthesis. TS-011 at a dose of 0.3 mg/kg inhibits the reduction in the blood flow velocities at 1 and 7 h after reperfusion (P<0.001). In addition, TS-011 inhibits the increase in the blood flow velocity at 24 h after reperfusion (P<0.01). TS-011 protects the microvascular perfusion area from the loss observed in vehicle-treated mice. TS-011, at a dose of 0.3 mg/kg, also reduces the infarct volume by almost 40% (P<0.05). In 9 dogs with delayed vasospasm, acute blockade of the synthesis of 20-HETE with TS-011 (1 mg/kg IV) significantly increases the diameter of the basilar artery by 39%.
  • Synonyms
    N-(3-Chloro-4-morpholinophenyl)-N'-hydroxyformimidamide
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    20-Hydroxyeicosatetraenoic acid synthesis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    339071-18-0
  • Formula Weight
    255.7
  • Molecular Formula
    C11H14ClN3O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 240 mg/mL?(938.60 mM;?Need ultrasonic)
  • SMILES
    ON=CNc(cc1)cc(Cl)c1N1CCOCC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Marumo T, et al. The inhibitor of 20-HETE synthesis, TS-011, improves cerebral microcirculatory autoregulation impaired by middle cerebral artery occlusion in mice. Br J Pharmacol. 2010 Nov;161(6):1391-402.
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