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Simufilam dihydrochloride

CAS No. 2480226-06-8

Simufilam dihydrochloride( PTI-125 dihydrochloride )

Catalog No. M24133 CAS No. 2480226-06-8

Simufilam dihydrochloride is a low toxicity, orally active filamin A (FLNA) activator, which can be used for the research of Alzheimer's disease.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 98 In Stock
5MG 87 In Stock
10MG 139 In Stock
25MG 294 In Stock
50MG 373 In Stock
100MG 486 In Stock
200MG 642 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Simufilam dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Simufilam dihydrochloride is a low toxicity, orally active filamin A (FLNA) activator, which can be used for the research of Alzheimer's disease.
  • Description
    Simufilam dihydrochloride is a low toxicity, orally active filamin A (FLNA) activator, which can be used for the research of Alzheimer's disease. Simufilam dihydrochloride preferentially binds altered FLNA and restores its native conformation, restoring receptor and synaptic activities and reducing its α7nAChR/TLR4 associations and downstream pathologies.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    PTI-125 dihydrochloride
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    filamin A (FLNA)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2480226-06-8
  • Formula Weight
    332.3
  • Molecular Formula
    C15H23Cl2N3O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    [H]Cl.O=C1N(CC2=CC=CC=C2)C3(CCN(C)CC3)NC1.[H]Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Wang HY, et al. PTI-125 binds and reverses an altered conformation of filamin A to reduce Alzheimer's disease pathogenesis. Neurobiol Aging. 2017;55:99-114.
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