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NRX-252262
CAS No. 2438637-61-5
NRX-252262( —— )
Catalog No. M24123 CAS No. 2438637-61-5
NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation(EC50:3.8 nM)
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 330 | In Stock |
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| 5MG | 273 | In Stock |
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| 10MG | 432 | In Stock |
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| 25MG | 715 | In Stock |
|
| 50MG | 986 | In Stock |
|
| 100MG | 1330 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNRX-252262
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NoteResearch use only, not for human use.
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Brief DescriptionNRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation(EC50:3.8 nM)
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DescriptionNRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation(EC50:3.8 nM).
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In VitroNRX-252262 (35?μM) causes S33E/S37A mutant β-catenin degradation in cells.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorSCF(β-TrCP)-E3 ligase
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Research Area——
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Indication——
Chemical Information
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CAS Number2438637-61-5
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Formula Weight545.36
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Molecular FormulaC23H17Cl2F3N2O4S
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Purity>98% (HPLC)
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SolubilityDMSO:8 mg/mL?(14.67 mM;?Need ultrasonic)
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SMILESO=C1C(C(N2CC3=C(C=C(OC)C(OC)=C3)C2)=O)=C(SC4=C(Cl)C=CC=C4Cl)C=C(C(F)(F)F)N1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Kyle R. Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nature Communications. 2019 March.
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