PF-06928215( —— )

Catalog No. M24095 CAS No. 2378173-15-8

PF-06928215 is an inhibitor of cGAS (cyclic GMP-AMP Synthase) (IC50 of 4.9 μΜ).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	188	In Stock
5MG	180	In Stock
10MG	264	In Stock
25MG	502	In Stock
50MG	715	In Stock
100MG	1004	In Stock
200MG	Get Quote	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

PF-06928215
Note

Research use only, not for human use.
Brief Description

PF-06928215 is an inhibitor of cGAS (cyclic GMP-AMP Synthase) (IC50 of 4.9 μΜ).
Description

PF-06928215 is an inhibitor of cGAS (cyclic GMP-AMP Synthase) (IC50 of 4.9 μΜ).
In Vitro

PF-06928215 displays no activity in cellular cGAS assays measuring dsDNA-induced IFN-beta expression.
In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

cGAS
Research Area

——
Indication

——

Chemical Information

CAS Number

2378173-15-8
Formula Weight

380.4
Molecular Formula

C20H20N4O4
Purity

>98% (HPLC)
Solubility

DMSO:33.33 mg/mL (87.62 mM; Need ultrasonic)
SMILES

OC1=CC(C2=CC=CC=C2)=NC3=C(C(N[C@H]4CCCC[C@H]4C(O)=O)=O)C=NN13
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Hall J, et al. Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay. PLoS One. 2017 Sep 21;12(9):e0184843.

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