LY-3475070
CAS No. 2375815-63-5
LY-3475070( EX-A4254 )
Catalog No. M24092 CAS No. 2375815-63-5
LY-3475070 is a potent and selective CD73 inhibitor with an IC50 of 28 nM, and its use alone or in combination with pembrolizumab is currently being tested in patients with advanced cancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 155 | In Stock |
|
| 5MG | 141 | In Stock |
|
| 10MG | 226 | In Stock |
|
| 25MG | 378 | In Stock |
|
| 50MG | 527 | In Stock |
|
| 100MG | 714 | In Stock |
|
| 200MG | 918 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameLY-3475070
-
NoteResearch use only, not for human use.
-
Brief DescriptionLY-3475070 is a potent and selective CD73 inhibitor with an IC50 of 28 nM, and its use alone or in combination with pembrolizumab is currently being tested in patients with advanced cancer.
-
DescriptionLY-3475070 is a potent and selective CD73 inhibitor with an IC50 of 28 nM, and its use alone or in combination with pembrolizumab is currently being tested in patients with advanced cancer.
-
In Vitro——
-
In Vivo——
-
SynonymsEX-A4254
-
PathwayOthers
-
TargetOther Targets
-
RecptorCD73
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2375815-63-5
-
Formula Weight286.33
-
Molecular FormulaC15H18N4O2
-
Purity>98% (HPLC)
-
SolubilityDMSO:10 mM
-
SMILESCC1=NN=C(C=C1[C@H]2C[C@@H]2C(C)C)C3=CNC(=O)NC3=O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
-
Suc-Leu-Tyr-AMC
Suc-Leu-Tyr-AMC is a fluorescent substrate for calpain I and II, papain (another cysteine protease), and is used to measure the chymotrypsin-like peptidase activity of the 20S proteasome (excitation max: 360 nm; emission max: 460 nm). Suc-Leu-Tyr-AMC can also be cleaved by the Ti protease from E. coli.
-
PAR-3 (1-6) (human)
PAR3 (1-6) is a synthetic peptide agonist of proteinase-activated receptor 1 (PAR1) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR3 and residues 39-44 of the full-length human sequence. PAR3 (1-6) activates p42/44 MAPK signaling in fibroblasts expressing PAR1, but not PAR3, an effect that can be blocked by the PAR1 antagonist RWJ 56110.
-
Maximaisoflavone B
Maximaisoflavone B
Cart
sales@molnova.com