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TRPV4 agonist-1
CAS No. 2314467-60-0
TRPV4 agonist-1( —— )
Catalog No. M24057 CAS No. 2314467-60-0
TRPV4 agonist-1 is an agonist of TRPV4 (EC50: 60 nM in the hTRPV4 Ca2+ assay).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | In Stock |
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| 50MG | 1782 | In Stock |
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| 100MG | 2250 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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Biological Information
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Product NameTRPV4 agonist-1
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NoteResearch use only, not for human use.
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Brief DescriptionTRPV4 agonist-1 is an agonist of TRPV4 (EC50: 60 nM in the hTRPV4 Ca2+ assay).
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DescriptionTRPV4 agonist-1 is an agonist of TRPV4 (EC50: 60 nM in the hTRPV4 Ca2+ assay).
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In VitroTRPV4 agonist-1 (Compound 36) exhibits significantly increased potency (ECmax: 20 nM in the SOX9 reporter assay). TRPV4 agonist-1 is inactive against TRPV1 channels.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorhTRPV4 Ca2+
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Research Area——
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Indication——
Chemical Information
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CAS Number2314467-60-0
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Formula Weight484.93
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Molecular FormulaC25H23ClF2N4O2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1N(C2=CC=C(OC3=CC=C(F)C=C3)C=C2)C(N4CCN(C)CC4)=NC5=C1C=CC=C5F.[H]Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Atobe M, et al. Discovery of Novel Transient Receptor Potential Vanilloid 4 (TRPV4) Agonists as Regulators of Chondrogenic Differentiation: Identification of Quinazolin-4(3 H)-ones and in Vivo Studies on a Surgically Induced Rat Model of Osteoarthritis. J Med Chem. 2019 Jan 28.
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