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ACH-000143
CAS No. 2225836-30-4
ACH-000143( —— )
Catalog No. M24008 CAS No. 2225836-30-4
ACH-000143 have been identified as a novel agonist of the melatonin receptors MT1 and MT2.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 124 | In Stock |
|
| 5MG | 112 | In Stock |
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| 10MG | 181 | In Stock |
|
| 25MG | 320 | In Stock |
|
| 50MG | 439 | In Stock |
|
| 100MG | 603 | In Stock |
|
| 200MG | 812 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameACH-000143
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NoteResearch use only, not for human use.
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Brief DescriptionACH-000143 have been identified as a novel agonist of the melatonin receptors MT1 and MT2.
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DescriptionACH-000143 have been identified as a novel agonist of the melatonin receptors MT1 and MT2.
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In Vitro——
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In VivoACH-000143 reduces liver triglycerides and steatosis in diet-Induced obese rats.ACH-000143 is devoid of hERG binding, genotoxicity, and behavioral alterations at doses up to 100 mg/kg p.o., supporting further investigation of this compound as a drug candidate.ACH-000143 significantly reduces plasma glucose at 10 mg/kg (?16.4%, p < 0.05) and 30 mg/kg (?16.9%, p < 0.01). Animal Model:High-fat diet rats.Dosage:10 and 30 mg/kg.Administration:Orally, once daily for two months.Result:Significantly reduced the weekly BW gain on weeks.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorMT1 receptor|MT2 receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number2225836-30-4
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Formula Weight297.74
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Molecular FormulaC13H16ClN3O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (167.93 mM)
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SMILESCC(NCCN1C2=CC(OC)=C(Cl)C=C2N=C1OC)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Marcos Antonio Ferreira Jr, et al. Discovery of ACH-000143: A Novel Potent and Peripherally Preferred Melatonin Receptor Agonist that Reduces Liver Triglycerides and Steatosis in Diet-Induced Obese Rats. J Med Chem. 2021 Feb 25;64(4):1904-1929.
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