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MA-0204
CAS No. 2095128-17-7
MA-0204( —— )
Catalog No. M23943 CAS No. 2095128-17-7
MA-0204 is a highly selective and orally available peroxisome proliferator-activated receptor δ (PPARδ) modulator.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 187 | In Stock |
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| 5MG | 179 | In Stock |
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| 10MG | 301 | In Stock |
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| 25MG | 489 | In Stock |
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| 50MG | 663 | In Stock |
|
| 100MG | 882 | In Stock |
|
| 200MG | 1181 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMA-0204
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NoteResearch use only, not for human use.
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Brief DescriptionMA-0204 is a highly selective and orally available peroxisome proliferator-activated receptor δ (PPARδ) modulator.
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DescriptionMA-0204 is a highly selective and orally available peroxisome proliferator-activated receptor δ (PPARδ) modulator (EC50s: 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively). It is a potential treatment for Duchene Muscular Dystrophy (DMD).
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In VitroMA-0204 is >10,000-fold selective for activation of PPARδ over PPARα and PPARγ receptors. MA-0204 exhibits high protein binding to mouse plasma, good permeability and low potential for efflux. C.MA-0204 (1.2-12 nM) improves fatty acid oxidation in DMD patient muscle myoblasts mice.MA-0204 (0.04-40 nM) engages target gene expression in DMD patient muscle myoblasts.
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In VivoPPARδ (30, 100 mg/kg) increases target gene transcription in the muscle.
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetPPAR
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RecptorPPARδ
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Research Area——
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Indication——
Chemical Information
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CAS Number2095128-17-7
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Formula Weight476.49
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Molecular FormulaC25H27F3N2O4
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Purity>98% (HPLC)
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SolubilityDMSO:40 mg/mL (83.95 mM; Need ultrasonic)
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SMILESC[C@H](CCCOc1c(Cn2c(-c(cc3)ccc3OC(F)(F)F)ncc2C)cccc1)CC(O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Lagu B, et al. Selective PPARδ Modulators Improve Mitochondrial Function: Potential Treatment for Duchenne Muscular Dystrophy (DMD). ACS Med Chem Lett. 2018 Jul 31;9(9):935-940.
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