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Giredestrant
CAS No. 1953133-47-5
Giredestrant( GDC-9545 )
Catalog No. M23885 CAS No. 1953133-47-5
Giredestrant potently competes with estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 259 | In Stock |
|
| 5MG | 224 | In Stock |
|
| 10MG | 353 | In Stock |
|
| 25MG | 679 | In Stock |
|
| 50MG | 1051 | In Stock |
|
| 100MG | 1665 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGiredestrant
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NoteResearch use only, not for human use.
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Brief DescriptionGiredestrant potently competes with estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor activity.
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DescriptionGiredestrant potently competes with estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor activity. Giredestrant, a non-steroidal ER ligand, is an orally active and selective estrogen receptor (ER) antagonist.
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In Vitro——
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In Vivo——
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SynonymsGDC-9545
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PathwayEndocrinology/Hormones
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TargetEstrogen Receptor/ERR
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RecptorER
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Research Area——
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Indication——
Chemical Information
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CAS Number1953133-47-5
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Formula Weight522.55
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Molecular FormulaC27H31F5N4O
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Purity>98% (HPLC)
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SolubilityDMSO:100mg/mL (191.37 mM; Need ultrasonic)
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SMILESC[C@H](Cc1c2[nH]c3c1cccc3)N(CC(CO)(F)F)[C@@H]2c(c(F)cc(NC1CN(CCCF)C1)c1)c1F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.C Metcalfe, et al. Abstract P5-04-07: GDC-9545: A novel ER antagonist and clinical candidate that combines desirable mechanistic and pre-clinical DMPK attributes
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