LDN-192960

Research use only, not for human use.

LDN-192960 is a potent inhibitor of Haspin and DYRK2 (IC50s: 10 nM and 48 nM).

LDN-192960 is a potent inhibitor of Haspin and DYRK2 (IC50s: 10 nM and 48 nM).

LDN-192960 (10 μM) is selective and inhibits ten of the other kinases by ≥90%, with only five being potently inhibited (IC50<1 μM),including CLK1 (IC50=0.21 μM), DYRK1A(IC50= 0.10 μM), DYRK2 (IC50=2 nM), DYRK3 (IC50=19 nM) and PIM1 (IC50=0.72 μM).LDN-0192960 (0-5 μM; 2 hours) demonstrates that the classical Haspin inhibition phenotype by reducing levels of p-Thr3H3 in HeLa cells overexpressing Haspin with an EC50 of 1.17 μM. LDN-0192960 (0-1 μM; 1 hour incubation in the presence of nocodazole and MG132) demonstrates the classical Haspin inhibition phenotype by reducing levels of p-Thr3H3 in HeLa cells synchronized in mitosis with an EC50 of 0.02 μM.

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Others

Other Targets

DYRK2| Haspin

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184582-62-5

328.43

C18H20N2O2S

>98% (HPLC)

DMSO:30 mg/mL (91.34 mM);Water:10 mg/mL (30.45 mM)

NCCCSC1=C(C=C(OC)C=C2)C2=NC3=CC=C(OC)C=C31

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(-20℃)

With Ice Pack

≥ 2 years