EGFR/ErbB2 Inhibitor( —— )

Catalog No. M23804 CAS No. 179248-61-4

EGFR/ErbB2 Inhibitor is a cell-permeable inhibitor of EGFR and c-ErbB2 (IC50s = 20 and 79 nM, respectively)

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	105	In Stock
5MG	95	In Stock
10MG	143	In Stock
25MG	259	In Stock
50MG	382	In Stock
100MG	554	In Stock
200MG	736	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

EGFR/ErbB2 Inhibitor
Note

Research use only, not for human use.
Brief Description

EGFR/ErbB2 Inhibitor is a cell-permeable inhibitor of EGFR and c-ErbB2 (IC50s = 20 and 79 nM, respectively)
Description

EGFR/ErbB2 Inhibitor is a cell-permeable inhibitor of EGFR and c-ErbB2 (IC50s = 20 and 79 nM, respectively).
In Vitro

EGFR/ErbB-2/ErbB-4 inhibitor-2 (Compound 5) also inhibits c-Src, VEGFR2, c-Fms and with IC50s of 0.30, 2.2, and 14.0 μM, respectively.
In Vivo

——
Synonyms

——
Pathway

Angiogenesis
Target

EGFR
Recptor

c-ErbB2|EGFR|ErbB2
Research Area

——
Indication

——

Chemical Information

CAS Number

179248-61-4
Formula Weight

387.43
Molecular Formula

C23H21N3O3
Purity

>98% (HPLC)
Solubility

DMSO:10 mM
SMILES

COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)OCC4=CC=CC=C4)OC
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Cockerill S , Stubberfield C , Stables J , et al. Indazolylamino quinazolines and pyridopyrimidines as inhibitors of the EGFr and C-erbB-2.[J]. Bioorganic & Medicinal Chemistry Letters, 2010, 32( 11):no-no.

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