EGFR/ErbB2 Inhibitor( —— )

Catalog No. M23804 CAS No. 179248-61-4

EGFR/ErbB2 Inhibitor is a cell-permeable inhibitor of EGFR and c-ErbB2 (IC50s = 20 and 79 nM, respectively)

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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10MG	408	In Stock
25MG	673	In Stock
50MG	945	In Stock
100MG	1278	In Stock
500MG	2547	In Stock
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Biological Information

Product Name

EGFR/ErbB2 Inhibitor
Note

Research use only, not for human use.
Brief Description

EGFR/ErbB2 Inhibitor is a cell-permeable inhibitor of EGFR and c-ErbB2 (IC50s = 20 and 79 nM, respectively)
Description

EGFR/ErbB2 Inhibitor is a cell-permeable inhibitor of EGFR and c-ErbB2 (IC50s = 20 and 79 nM, respectively).
In Vitro

EGFR/ErbB-2/ErbB-4 inhibitor-2 (Compound 5) also inhibits c-Src, VEGFR2, c-Fms and with IC50s of 0.30, 2.2, and 14.0 μM, respectively.
In Vivo

——
Synonyms

——
Pathway

Angiogenesis
Target

EGFR
Recptor

c-ErbB2|EGFR|ErbB2
Research Area

——
Indication

——

Chemical Information

CAS Number

179248-61-4
Formula Weight

387.43
Molecular Formula

C23H21N3O3
Purity

>98% (HPLC)
Solubility

DMSO:10 mM
SMILES

COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)OCC4=CC=CC=C4)OC
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Cockerill S , Stubberfield C , Stables J , et al. Indazolylamino quinazolines and pyridopyrimidines as inhibitors of the EGFr and C-erbB-2.[J]. Bioorganic & Medicinal Chemistry Letters, 2010, 32( 11):no-no.

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