Cart
sales@molnova.com
EGFR/ErbB2 Inhibitor
CAS No. 179248-61-4
EGFR/ErbB2 Inhibitor( —— )
Catalog No. M23804 CAS No. 179248-61-4
EGFR/ErbB2 Inhibitor is a cell-permeable inhibitor of EGFR and c-ErbB2 (IC50s = 20 and 79 nM, respectively)
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 105 | In Stock |
|
| 5MG | 95 | In Stock |
|
| 10MG | 143 | In Stock |
|
| 25MG | 259 | In Stock |
|
| 50MG | 382 | In Stock |
|
| 100MG | 554 | In Stock |
|
| 200MG | 736 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameEGFR/ErbB2 Inhibitor
-
NoteResearch use only, not for human use.
-
Brief DescriptionEGFR/ErbB2 Inhibitor is a cell-permeable inhibitor of EGFR and c-ErbB2 (IC50s = 20 and 79 nM, respectively)
-
DescriptionEGFR/ErbB2 Inhibitor is a cell-permeable inhibitor of EGFR and c-ErbB2 (IC50s = 20 and 79 nM, respectively).
-
In VitroEGFR/ErbB-2/ErbB-4 inhibitor-2 (Compound 5) also inhibits c-Src, VEGFR2, c-Fms and with IC50s of 0.30, 2.2, and 14.0 μM, respectively.
-
In Vivo——
-
Synonyms——
-
PathwayAngiogenesis
-
TargetEGFR
-
Recptorc-ErbB2|EGFR|ErbB2
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number179248-61-4
-
Formula Weight387.43
-
Molecular FormulaC23H21N3O3
-
Purity>98% (HPLC)
-
SolubilityDMSO:10 mM
-
SMILESCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)OCC4=CC=CC=C4)OC
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Cockerill S , Stubberfield C , Stables J , et al. Indazolylamino quinazolines and pyridopyrimidines as inhibitors of the EGFr and C-erbB-2.[J]. Bioorganic & Medicinal Chemistry Letters, 2010, 32( 11):no-no.
molnova catalog
related products
-
Pyrotinib maleate
Pyrotinib maleate (SHR-1258 maleate)?is a potent and selective EGFR/HER2 dual inhibitor with IC50 of 13/38 nM, respectively.
-
AG-1517
PD153035 hydrochloride is a potent and specific inhibitor of EGFR with Ki and IC50 of 5.2 pM and 29 pM in cell-free assays; little effect noted against PGDFR, FGFR, CSF-1, InsR and Src.
-
Sunvozertinib
Sunvozertinib (DZD9008) is a potent ErbBs and BTK inhibitor, with inhibitory effects on EGFR, Her2, and mutant epidermal growth factor.
