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EGFR/ErbB2 Inhibitor

CAS No. 179248-61-4

EGFR/ErbB2 Inhibitor( —— )

Catalog No. M23804 CAS No. 179248-61-4

EGFR/ErbB2 Inhibitor is a cell-permeable inhibitor of EGFR and c-ErbB2 (IC50s = 20 and 79 nM, respectively)

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 105 In Stock
5MG 95 In Stock
10MG 143 In Stock
25MG 259 In Stock
50MG 382 In Stock
100MG 554 In Stock
200MG 736 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    EGFR/ErbB2 Inhibitor
  • Note
    Research use only, not for human use.
  • Brief Description
    EGFR/ErbB2 Inhibitor is a cell-permeable inhibitor of EGFR and c-ErbB2 (IC50s = 20 and 79 nM, respectively)
  • Description
    EGFR/ErbB2 Inhibitor is a cell-permeable inhibitor of EGFR and c-ErbB2 (IC50s = 20 and 79 nM, respectively).
  • In Vitro
    EGFR/ErbB-2/ErbB-4 inhibitor-2 (Compound 5) also inhibits c-Src, VEGFR2, c-Fms and with IC50s of 0.30, 2.2, and 14.0 μM, respectively.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    EGFR
  • Recptor
    c-ErbB2|EGFR|ErbB2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    179248-61-4
  • Formula Weight
    387.43
  • Molecular Formula
    C23H21N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:10 mM
  • SMILES
    COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)OCC4=CC=CC=C4)OC
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Cockerill S , Stubberfield C , Stables J , et al. Indazolylamino quinazolines and pyridopyrimidines as inhibitors of the EGFr and C-erbB-2.[J]. Bioorganic & Medicinal Chemistry Letters, 2010, 32( 11):no-no.
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