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OSMI-1
CAS No. 1681056-61-0
OSMI-1( —— )
Catalog No. M23755 CAS No. 1681056-61-0
OSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 84 | In Stock |
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| 2MG | 46 | In Stock |
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| 5MG | 73 | In Stock |
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| 10MG | 120 | In Stock |
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| 25MG | 197 | In Stock |
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| 50MG | 343 | In Stock |
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| 100MG | 511 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameOSMI-1
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NoteResearch use only, not for human use.
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Brief DescriptionOSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans.
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DescriptionOSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans. OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor (IC50: 2.7 μM).
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In VitroOSMI-1 (50 μM; 24 hours; CHO cells) treatment decreases the viability by about 50% after 24 hours.OSMI-1 (10-100 μM; 24 hours; CHO cells) treatment reduces global O-linked N-acetylglucosamine (O-GlcNAcylation) a dose-dependent manner. OSMI-1 inhibits OGT activity in cells. Cell Viability Assay Cell Line:CHO cells Concentration:50 μM Incubation Time:24 hours Result:Viability decreased by about 50% after 24 hours.Western Blot Analysis Cell Line:CHO cells Concentration:10 μM, 25 μM, 50 μM, 100 μM Incubation Time:24 hours Result:Reduced global OGlcNAcylation in a dose-dependent manner.
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In VivoMammalian and zebrafish toxicity profiles are strikingly similar, and zebrafish can usually serve as an intermediate step between cell-based evaluation and conventional animal testing. The zebrafish model is used to investigate OSM1-1 acute toxicity in vivo. The LC50 of OSM1-1 is 0.031?mg/mL (56?μM, 12?h) and 0.025?mg/mL (45?μM, 24?h) in zebrafish model.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorO-GlcNAc transferase (OGT)
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Research Area——
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Indication——
Chemical Information
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CAS Number1681056-61-0
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Formula Weight563.64
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Molecular FormulaC28H25N3O6S2
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Purity>98% (HPLC)
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SolubilityDMSO:83.33 mg/mL?(147.84 mM;?Need ultrasonic)
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SMILESO=C(N(CC1=CC=CS1)CC2=CC=CO2)[C@H](NS(C3=CC(C=C4)=C(C=C3)NC4=O)(=O)=O)C5=CC=CC=C5OC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Ortiz-Meoz RF, et al. A small molecule that inhibits OGT activity in cells. ACS Chem Biol. 2015 Jun 19;10(6):1392-7.
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