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TAS6417

CAS No. 1661854-97-2

TAS6417( —— )

Catalog No. M23746 CAS No. 1661854-97-2

TAS6417 is an EGFR inhibitor and is an efficacious drug candidate for patients with NSCLC.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 215 In Stock
2MG 120 In Stock
5MG 188 In Stock
10MG 312 In Stock
25MG 629 In Stock
50MG 821 In Stock
100MG 1107 In Stock
200MG 1516 In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    TAS6417
  • Note
    Research use only, not for human use.
  • Brief Description
    TAS6417 is an EGFR inhibitor and is an efficacious drug candidate for patients with NSCLC.
  • Description
    TAS6417 is an EGFR inhibitor and is an efficacious drug candidate for patients with NSCLC (IC50: ranging from 1.1-8.0 nM).
  • In Vitro
    Apoptosis Analysis Cell Line:PC-9, H1975, BID007, BID019, BEAS-2B cells.Concentration:0-10 μM.Incubation Time:24-48 h.Result:Led to apoptosis via inhibition of mutant EGFR.
  • In Vivo
    Animal Model:Mice implanted with NCI-H1975 EGFR D770_N771insSVD xenografts.Dosage:50 and 100 mg/kg.Administration:Orally once daily for 14 days.Result:Showed marked tumor growth inhibition with treatment/control (T/C) ratios of 51% and 19%, respectively.
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis|EGFR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1661854-97-2
  • Formula Weight
    396.44
  • Molecular Formula
    C23H20N6O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:125 mg/mL (315.31 mM)
  • SMILES
    CC1=C[C@@H](CN2C1=C(C3=C(N=CN=C32)N)C4=CC5=CC=CC=C5N=C4)NC(=O)C=C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Hasako S, et al. TAS6417, A Novel EGFR Inhibitor Targeting Exon 20 Insertion Mutations. Mol Cancer Ther. 2018 Aug;17(8):1648-1658.
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