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TAS6417

CAS No. 1661854-97-2

TAS6417( —— )

Catalog No. M23746 CAS No. 1661854-97-2

TAS6417 is an EGFR inhibitor and is an efficacious drug candidate for patients with NSCLC.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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25MG 597 In Stock
50MG 954 In Stock
100MG 1467 In Stock
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Biological Information

  • Product Name
    TAS6417
  • Note
    Research use only, not for human use.
  • Brief Description
    TAS6417 is an EGFR inhibitor and is an efficacious drug candidate for patients with NSCLC.
  • Description
    TAS6417 is an EGFR inhibitor and is an efficacious drug candidate for patients with NSCLC (IC50: ranging from 1.1-8.0 nM).
  • In Vitro
    Apoptosis Analysis Cell Line:PC-9, H1975, BID007, BID019, BEAS-2B cells.Concentration:0-10 μM.Incubation Time:24-48 h.Result:Led to apoptosis via inhibition of mutant EGFR.
  • In Vivo
    Animal Model:Mice implanted with NCI-H1975 EGFR D770_N771insSVD xenografts.Dosage:50 and 100 mg/kg.Administration:Orally once daily for 14 days.Result:Showed marked tumor growth inhibition with treatment/control (T/C) ratios of 51% and 19%, respectively.
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis|EGFR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1661854-97-2
  • Formula Weight
    396.44
  • Molecular Formula
    C23H20N6O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:125 mg/mL (315.31 mM)
  • SMILES
    CC1=C[C@@H](CN2C1=C(C3=C(N=CN=C32)N)C4=CC5=CC=CC=C5N=C4)NC(=O)C=C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Hasako S, et al. TAS6417, A Novel EGFR Inhibitor Targeting Exon 20 Insertion Mutations. Mol Cancer Ther. 2018 Aug;17(8):1648-1658.
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