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LNP023 hydrochloride

CAS No. 1646321-63-2

LNP023 hydrochloride( Iptacopan HCl )

Catalog No. M23738 CAS No. 1646321-63-2

LNP023 hydrochloride is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 117 In Stock
2MG 70 In Stock
5MG 117 In Stock
10MG 196 In Stock
25MG 353 In Stock
50MG 578 In Stock
100MG 958 In Stock
200MG 1293 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    LNP023 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    LNP023 hydrochloride is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM.
  • Description
    LNP023 hydrochloride is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM. LNP023 shows direct, reversible, and high-affinity binding to human factor B with a KD of 7.9 nM.
  • In Vitro
    ——
  • In Vivo
    Animal Model:C57BL/6 mice with KRN-induced arthritis Dosage:20, 60, and 180 mg/kg Administration:Orally gavaged; twice a day (b.i.d.) for 14 days Result:Blocked KRN-induced arthritis.
  • Synonyms
    Iptacopan HCl
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    factor B
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1646321-63-2
  • Formula Weight
    458.98
  • Molecular Formula
    C25H31ClN2O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:250 mg/mL (544.69 mM; Need ultrasonic);H2O:50 mg/mL (108.94 mM; ultrasonic and warming)
  • SMILES
    O=C(O)C1=CC=C([C@H]2N(CC3=C(OC)C=C(C)C4=C3C=CN4)CC[C@H](OCC)C2)C=C1.[H]Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Dimitrios C Mastellos, et al. Expanding Complement Therapeutics for the Treatment of Paroxysmal Nocturnal Hemoglobinuria. Semin Hematol. 2018 Jul;55(3):167-175.
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