Cart
sales@molnova.com
Zinc Protoporphyrin
CAS No. 15442-64-5
Zinc Protoporphyrin( Zn(II)-protoporphyrin IX | ZnPP | Zinc Protoporphyrin-9 )
Catalog No. M23667 CAS No. 15442-64-5
Zinc Protoporphyrin is an orally active and competitive inhibitor of heme oxygenase-1 (HO-1) and markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2, and has anti-cancer activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 55 | In Stock |
|
| 5MG | 40 | In Stock |
|
| 10MG | 61 | In Stock |
|
| 25MG | 103 | In Stock |
|
| 50MG | 147 | In Stock |
|
| 100MG | 219 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameZinc Protoporphyrin
-
NoteResearch use only, not for human use.
-
Brief DescriptionZinc Protoporphyrin is an orally active and competitive inhibitor of heme oxygenase-1 (HO-1) and markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2, and has anti-cancer activity.
-
DescriptionZinc Protoporphyrin is an orally active and competitive inhibitor of heme oxygenase-1 (HO-1) and markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2, and has anti-cancer activity.
-
In VitroApoptosis Analysis Cell Line:C-26 cells Concentration:5 μM Incubation Time:72 hoursResult:The fraction of late apoptotic and necrotic cells increased from 10.9% in controls to 30.4% after 72 h.Cell Cytotoxicity Assay Cell Line:C-26 and MDA-MB231 cells Concentration:1.25, 2.5, 5, 10, 20, 40 μM Incubation Time:48 or 72 hours Result:Exerted cystostatic/cytotoxic effects against tumor cells.Cell Cycle Analysis Cell Line:C-26 cells Concentration:2.5, 5 μM Incubation Time:48 or 72 hours Result:Resulted in dose- and time-dependent reduction of cells in G1 phase of the cell cycle. Western Blot Analysis Cell Line:C-26 cells Concentration:1.25, 2.5, 5, 10, 20, 40 μM Incubation Time:48 hoursResult:Leaded to accumulation of cleaved (active) caspase-3.
-
In VivoAnimal Model:BALB/c mice inoculated with C-26 cells Dosage:12.5, 25, 50 mg/kg for i.p.; 12.5, 50 mg/kg for p.o.Administration:IP or PO; from day 7 to 19 Result:Exerted dose-dependent antitumor effects manifested by the retardation of tumor growth.
-
SynonymsZn(II)-protoporphyrin IX | ZnPP | Zinc Protoporphyrin-9
-
PathwayProteasome/Ubiquitin
-
TargetEndogenous Metabolite
-
RecptorHuman Endogenous Metabolite|Reactive Oxygen Species
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number15442-64-5
-
Formula Weight626.02
-
Molecular FormulaC34H32N4O4Zn
-
Purity>98% (HPLC)
-
SolubilityDMSO:50 mg/mL (79.87 mM; Need ultrasonic);H2O:< 0.1 mg/mL (insoluble)
-
SMILESOC(CCC1=C(C=C2[N]3=C4C(C)=C2CCC(O)=O)[N-]([Zn+2]35[N]6=C7C=C(C(C=C)=C8C)[N-]5C8=C4)C(C=C6C(C=C)=C7C)=C1C)=O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
-
Diethyl oxalpropiona...
Diethyl oxalpropionate also known as methyloxalacetic acid diethyl ester or diethyl methyloxalacetate is a member of the class of compounds known as beta-keto acids and derivatives. These compounds are organic compounds containing an aldehyde substituted with a keto group on the C3 carbon atom.
-
11(Z),14(Z),17(Z)-Ei...
11(Z),14(Z),17(Z)-Eicosatrienoic acid is an unsaturated fatty acid capable of maintaining continuous replication of functional mitochondria in Saccharomyces cerevisiae (KD115).
-
Aflatoxin B1
Aflatoxin B1 (AFB1) is a Group 1A carcinogen and a secondary metabolite produced by Aspergillus flavus and A. parasiticus. Aflatoxin B1 (AFB1) primarily induces mutations by causing a G to T transversion at the third nucleotide of codon 249 in the tumor suppressor gene p53. In the body, Aflatoxin B1 (AFB1) can cause damage to the intestines and kidneys and has some teratogenic effects.
