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Lifirafenib
CAS No. 1446090-79-4
Lifirafenib( Beigene-283 | BGB-283 )
Catalog No. M23610 CAS No. 1446090-79-4
Lifirafenib is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain, EGFR and EGFR T790M/L858R mutant respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 95 | In Stock |
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| 100MG | 827 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameLifirafenib
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NoteResearch use only, not for human use.
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Brief DescriptionLifirafenib is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain, EGFR and EGFR T790M/L858R mutant respectively.
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DescriptionLifirafenib is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain, EGFR and EGFR T790M/L858R mutant respectively.
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In VitroLifirafenib (BGB-283) potently inhibits BRafV600E-activated ERK phosphorylation and cell proliferation. It demonstrates selective cytotoxicity and preferentially inhibits proliferation of cancer cells harboring BRafV600E and EGFR mutation/amplification. In BRafV600E colorectal cancer cell lines, Lifirafenib (BGB-283) effectively inhibits the reactivation of EGFR and EGFR-mediated cell proliferation.
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In VivoLifirafenib (BGB-283) treatment leads to dose-dependent tumor growth inhibition accompanied by partial and complete tumor regressions in both cell line-derived and primary human colorectal tumor xenografts bearing BRafV600E mutation.
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SynonymsBeigene-283 | BGB-283
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PathwayAngiogenesis
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TargetEGFR
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RecptorB-Raf (V600E)|EGFR|EGFR (L858R/T790M)
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Research Area——
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Indication——
Chemical Information
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CAS Number1446090-79-4
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Formula Weight478.42
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Molecular FormulaC25H17F3N4O3
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Purity>98% (HPLC)
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SolubilityDMSO:100 mg/mL (209.02 mM)
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SMILESO=C1Nc2nccc(Oc(cc3)cc(C45)c3OC4C5c3nc(ccc(C(F)(F)F)c4)c4[nH]3)c2CC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Tang Z, et al. Mol Cancer Ther. 2015, 14(10):2187-97.
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