SIRT-IN-2( —— )

Catalog No. M23596 CAS No. 1431411-66-3

SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Biological Information

Product Name

SIRT-IN-2
Note

Research use only, not for human use.
Brief Description

SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).
Description

SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).
In Vitro

SIRT-IN-2 (compound 31) is one of the most potent truncated pan SIRT1/ 2/3 inhibitor, the IC50 values are 4, 4, 7 μM, respectively. SIRT-IN-2 (SIRT1/2/3 pan inhibitor) binds identically in the catalytic active site (RMS=0.29 ?), occupying the nicotinamide C-pocket and acetyl lysine substrate channel.
In Vivo

——
Synonyms

——
Pathway

Chromatin/Epigenetic
Target

Sirtuin
Recptor

SIRT1|SIRT2|SIRT3
Research Area

——
Indication

——

Chemical Information

CAS Number

1431411-66-3
Formula Weight

383.49
Molecular Formula

C15H21N5O3S2
Purity

>98% (HPLC)
Solubility

DMSO:62.5 mg/mL?(151.24 mM;?Need ultrasonic)
SMILES

CS(NCCC(CC1)CCN1c1ncnc2c1sc(C(N)=O)c2)(=O)=O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Disch JS, et al. Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3. J Med Chem. 2013 May 9;56(9):3666-79.

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