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Home - Products - Metabolic Enzyme/Protease - P450 - Soticlestat

Soticlestat

CAS No. 1429505-03-2

Soticlestat( OV935 | TAK-935 )

Catalog No. M23591 CAS No. 1429505-03-2

Soticlestat is a potent, selective and orally active cholesterol 24-hydroxylase (CYP46A1) inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 154 In Stock
5MG 140 In Stock
10MG 227 In Stock
25MG 454 In Stock
50MG 640 In Stock
100MG 926 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Soticlestat
  • Note
    Research use only, not for human use.
  • Brief Description
    Soticlestat is a potent, selective and orally active cholesterol 24-hydroxylase (CYP46A1) inhibitor.
  • Description
    Soticlestat is a potent, selective and orally active cholesterol 24-hydroxylase (CYP46A1) inhibitor. It has the potential for epilepsy syndromes research.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Amyloid precursor protein and presenilin 1 (APP/PS1-Tg) mice (7-week-old)Dosage:10 mg/kg Administration:Oral administration; once daily; for 1 days, 3 days and 7 days Result:Lowered brain 24S-hydroxycholesterol in a dose-dependent manner and substantially reduced premature deaths of APP/PS1-Tg mice at a dose lowering brain 24S-hydroxycholesterol by approximately 50%.
  • Synonyms
    OV935 | TAK-935
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    P450
  • Recptor
    CYP46A1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1429505-03-2
  • Formula Weight
    373.46
  • Molecular Formula
    C23H23N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:100 mg/mL (267.77 mM; Need ultrasonic)
  • SMILES
    C1CN(CCC1(CC2=CC=CC=C2)O)C(=O)C3=C(N=CC=C3)C4=CC=NC=C4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Toshiya Nishi, et al. Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice. Sci Rep. 2020 Oct 13;10(1):17081.
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