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Soticlestat
CAS No. 1429505-03-2
Soticlestat( OV935 | TAK-935 )
Catalog No. M23591 CAS No. 1429505-03-2
Soticlestat is a potent, selective and orally active cholesterol 24-hydroxylase (CYP46A1) inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 154 | In Stock |
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| 5MG | 140 | In Stock |
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| 10MG | 227 | In Stock |
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| 25MG | 454 | In Stock |
|
| 50MG | 640 | In Stock |
|
| 100MG | 926 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSoticlestat
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NoteResearch use only, not for human use.
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Brief DescriptionSoticlestat is a potent, selective and orally active cholesterol 24-hydroxylase (CYP46A1) inhibitor.
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DescriptionSoticlestat is a potent, selective and orally active cholesterol 24-hydroxylase (CYP46A1) inhibitor. It has the potential for epilepsy syndromes research.
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In Vitro——
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In VivoAnimal Model:Amyloid precursor protein and presenilin 1 (APP/PS1-Tg) mice (7-week-old)Dosage:10 mg/kg Administration:Oral administration; once daily; for 1 days, 3 days and 7 days Result:Lowered brain 24S-hydroxycholesterol in a dose-dependent manner and substantially reduced premature deaths of APP/PS1-Tg mice at a dose lowering brain 24S-hydroxycholesterol by approximately 50%.
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SynonymsOV935 | TAK-935
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PathwayMetabolic Enzyme/Protease
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TargetP450
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RecptorCYP46A1
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Research Area——
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Indication——
Chemical Information
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CAS Number1429505-03-2
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Formula Weight373.46
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Molecular FormulaC23H23N3O2
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Purity>98% (HPLC)
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SolubilityDMSO:100 mg/mL (267.77 mM; Need ultrasonic)
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SMILESC1CN(CCC1(CC2=CC=CC=C2)O)C(=O)C3=C(N=CC=C3)C4=CC=NC=C4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Toshiya Nishi, et al. Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice. Sci Rep. 2020 Oct 13;10(1):17081.
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