Cart
sales@molnova.com
Soticlestat
CAS No. 1429505-03-2
Soticlestat( OV935 | TAK-935 )
Catalog No. M23591 CAS No. 1429505-03-2
Soticlestat is a potent, selective and orally active cholesterol 24-hydroxylase (CYP46A1) inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 154 | In Stock |
|
| 5MG | 140 | In Stock |
|
| 10MG | 227 | In Stock |
|
| 25MG | 454 | In Stock |
|
| 50MG | 640 | In Stock |
|
| 100MG | 926 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameSoticlestat
-
NoteResearch use only, not for human use.
-
Brief DescriptionSoticlestat is a potent, selective and orally active cholesterol 24-hydroxylase (CYP46A1) inhibitor.
-
DescriptionSoticlestat is a potent, selective and orally active cholesterol 24-hydroxylase (CYP46A1) inhibitor. It has the potential for epilepsy syndromes research.
-
In Vitro——
-
In VivoAnimal Model:Amyloid precursor protein and presenilin 1 (APP/PS1-Tg) mice (7-week-old)Dosage:10 mg/kg Administration:Oral administration; once daily; for 1 days, 3 days and 7 days Result:Lowered brain 24S-hydroxycholesterol in a dose-dependent manner and substantially reduced premature deaths of APP/PS1-Tg mice at a dose lowering brain 24S-hydroxycholesterol by approximately 50%.
-
SynonymsOV935 | TAK-935
-
PathwayMetabolic Enzyme/Protease
-
TargetP450
-
RecptorCYP46A1
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1429505-03-2
-
Formula Weight373.46
-
Molecular FormulaC23H23N3O2
-
Purity>98% (HPLC)
-
SolubilityDMSO:100 mg/mL (267.77 mM; Need ultrasonic)
-
SMILESC1CN(CCC1(CC2=CC=CC=C2)O)C(=O)C3=C(N=CC=C3)C4=CC=NC=C4
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Toshiya Nishi, et al. Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice. Sci Rep. 2020 Oct 13;10(1):17081.
molnova catalog
related products
-
AG 045572
AG 045572 is a potent GnRH receptor antagonist that inhibits the GnRH receptor in humans and rats with Ki values of 6.0 nM and 3.8 nM, respectively.AG 045572 is metabolized by CYP3A and inhibits testosterone.
-
Enerisant HCl
Enerisant HCl is a novel potent and selective histamine H3 receptor antagonist, a substrate for P-gp, mediated by cytochrome P450 (CYP) and transporter proteins.
-
Ginsenoside Rb3
Ginsenoside Rb3 is a natural triterpenoid saponin, exhibiting inhibition effect on TNFα-induced NF-κB transcriptional activity. It also inhibits the induction of COX-2 and iNOS mRNA.
