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Sarolaner
CAS No. 1398609-39-6
Sarolaner( PF-6450567 )
Catalog No. M23553 CAS No. 1398609-39-6
Sarolaner is an orally active and broad-spectrum ectoparasiticide (LC80: 0.3 μg/mL against C. felis and an LC100: 0.003 μg/mL against O. turicata).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 128 | In Stock |
|
| 5MG | 92 | In Stock |
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| 10MG | 169 | In Stock |
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| 25MG | 359 | In Stock |
|
| 50MG | 528 | In Stock |
|
| 100MG | 758 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSarolaner
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NoteResearch use only, not for human use.
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Brief DescriptionSarolaner is an orally active and broad-spectrum ectoparasiticide (LC80: 0.3 μg/mL against C. felis and an LC100: 0.003 μg/mL against O. turicata).
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DescriptionSarolaner is an orally active and broad-spectrum ectoparasiticide (LC80: 0.3 μg/mL against C. felis and an LC100: 0.003 μg/mL against O. turicata).
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In VitroCell Viability Assay Cell Line:CHO-K1 cell lines Concentration:450 nM-1 mM Incubation Time:5 min Result:Inhibited GABA-elicited currents at both susceptible (CfRDL-A285) and resistant (CfRDL-S285) flea GABACls with EC50s of 135 and 136 nM, respectively.
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In VivoAnimal Model:Dog infested with R. sanguineus and D. reticulatus Dosage:2.5 mg/kg Administration:Oral gavage; 2.5 mg/kg once Result:Exibited 100% efficacy against R. sanguineus at 48 hours after treatment and also exhibited 98.0% efficacy against D. reticulatus.Animal Model:Dog infested with I. ricinus Dosage:1.25, 2.5 and 5 mg/kg Administration:Oral gavage; 1.25, 2.5 and 5 mg/kg once Result:Exibited 100% efficacy against I. ricinus at all doses until 7 days, and provided over 99.3% reduction against subsequent re-infestations until 57 days at dose of 5.0 and 2.5 mg/kg.
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SynonymsPF-6450567
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PathwayOthers
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TargetOther Targets
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RecptorLC80|LC100
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Research Area——
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Indication——
Chemical Information
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CAS Number1398609-39-6
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Formula Weight581.36
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Molecular FormulaC23H18Cl2F4N2O5S
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Purity>98% (HPLC)
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SolubilityDMSO : 290 mg/mL (498.83 mM; Need ultrasonic)
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SMILESO=S(CC(N1CC2(OCC3=C2C=CC(C4=NO[C@](C(F)(F)F)(C5=CC(Cl)=C(F)C(Cl)=C5)C4)=C3)C1)=O)(C)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.McTier TL, et al. Discovery of sarolaner: A novel, orally administered, broad-spectrum, isoxazoline ectoparasiticide for dogs. Vet Parasitol. 2016 May 30;222:3-11.
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