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Fedratinib hydrochloride hydrate
CAS No. 1374744-69-0
Fedratinib hydrochloride hydrate( TG-101348 hydrochloride hydrate | SAR 302503 hydrochloride hydrate )
Catalog No. M23532 CAS No. 1374744-69-0
Fedratinib hydrochloride hydrate is a potent, selective, ATP-competitive and orally active JAK2 inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 58 | In Stock |
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| 5MG | 37 | In Stock |
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| 10MG | 52 | In Stock |
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| 25MG | 74 | In Stock |
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| 50MG | 95 | In Stock |
|
| 100MG | 113 | In Stock |
|
| 200MG | 183 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameFedratinib hydrochloride hydrate
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NoteResearch use only, not for human use.
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Brief DescriptionFedratinib hydrochloride hydrate is a potent, selective, ATP-competitive and orally active JAK2 inhibitor.
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DescriptionFedratinib hydrochloride hydrate is a potent, selective, ATP-competitive and orally active JAK2 inhibitor.
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In Vitro——
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In VivoAnimal Model:C57Bl/6 mice induced by the JAK2V617F mutation Dosage:60 mg/kg, 120 mg/kg Administration:Oral gavage; twice daily; for 42 days Result:Showed a statistically significant reduction in hematocrit and leukocyte count, a dose-dependent reduction/elimination of extramedullary hematopoiesis.
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SynonymsTG-101348 hydrochloride hydrate | SAR 302503 hydrochloride hydrate
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PathwayAngiogenesis
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TargetJAK
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RecptorJAK2|JAK2 (V617F)
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Research Area——
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Indication——
Chemical Information
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CAS Number1374744-69-0
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Formula Weight615.61
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Molecular FormulaC27H40Cl2N6O4S
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Purity>98% (HPLC)
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SolubilityDMSO:120 mg/mL (194.92 mM; Need ultrasonic)；H2O:97 mg/mL (157.56 mM; Need ultrasonic)
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SMILESO=S(C1=CC=CC(NC2=NC(NC3=CC=C(OCCN4CCCC4)C=C3)=NC=C2C)=C1)(NC(C)(C)C)=O.[H]Cl.[H]Cl.[H]O[H]
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Wernig G, et al. Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera. Cancer Cell. 2008 Apr;13(4):311-20.
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