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4-P-PDOT

CAS No. 134865-74-0

4-P-PDOT( 4-phenyl-2- propionamidotetralin )

Catalog No. M23510 CAS No. 134865-74-0

4-P-PDOT is a potent, selective and affinity Melatonin receptor (MT2) antagonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 54 In Stock
2MG 31 In Stock
5MG 49 In Stock
10MG 85 In Stock
25MG 177 In Stock
50MG 276 In Stock
100MG 481 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    4-P-PDOT
  • Note
    Research use only, not for human use.
  • Brief Description
    4-P-PDOT is a potent, selective and affinity Melatonin receptor (MT2) antagonist.
  • Description
    4-P-PDOT is a potent, selective and affinity Melatonin receptor (MT2) antagonist.
  • In Vitro
    Cell Viability Assay Cell Line:HT-29 and HeLa cells.Concentration:50 μM Incubation Time:30 min Result:Produced a negligible effect on cell viability induced by melatonin.
  • In Vivo
    Animal Model:Klotho mutant mice treatment with Melatonin Dosage:0.5 mg/kg or 1.0 mg/kg Administration:Intravenous injection Result:Significantly reversed antioxidant effects mediated by Melatonin. Significantly reversed the changes in the levels of these GSH-related parameters. Significantly reversed the memory function of Melatonin-treated klotho mutant mice.
  • Synonyms
    4-phenyl-2- propionamidotetralin
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    MT2 receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    134865-74-0
  • Formula Weight
    279.38
  • Molecular Formula
    C19H21NO
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:41.67 mg/mL (149.15 mM; Need ultrasonic)
  • SMILES
    CCC(=O)NC1CC(C2=CC=CC=C2C1)C3=CC=CC=C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Dubocovich ML. Melatonin receptors: are there multiple subtypes? Trends Pharmacol Sci. 1995 Feb;16(2):50-6.
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