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SAR7334
CAS No. 1333210-07-3
SAR7334( TRCP6-IN-1 )
Catalog No. M23484 CAS No. 1333210-07-3
SAR7334 is a potent and specific inhibitor of TRPC6(IC50 of 7.9 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 169 | In Stock |
|
| 2MG | 90 | In Stock |
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| 5MG | 155 | In Stock |
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| 10MG | 250 | In Stock |
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| 25MG | 312 | In Stock |
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| 50MG | 361 | In Stock |
|
| 100MG | 454 | In Stock |
|
| 200MG | 649 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSAR7334
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NoteResearch use only, not for human use.
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Brief DescriptionSAR7334 is a potent and specific inhibitor of TRPC6(IC50 of 7.9 nM).
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DescriptionSAR7334 is a potent and specific inhibitor of TRPC6(IC50 of 7.9 nM).
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In VitroSAR7334 inhibits TRPC6, TRPC3 and TRPC7-mediated Ca2+ influx into cells with IC50s of 9.5, 282 and 226?nM, whereas TRPC4 and TRPC5-mediated Ca2+ entry is not affected. SAR7334 (1?μM) results in a major block of the Ang II-evoked calcium influx in the podocytes. SAR7334 (1 μM) has negligible effect on SOCE. SAR7334 dose-dependently reduces TRPC6 currents with an IC50 of 7.9?nM. SAR7334 (100?nM) substantially reduces TRPC6 currents.
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In VivoSAR7334 (10?mg/kg, p.o.) suppresses TRPC6-dependent acute HPV in isolated perfused lungs from mice. SAR7334 demonstrates that it is suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR).
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SynonymsTRCP6-IN-1
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PathwayMembrane Transporter/Ion Channel
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TargetTRP/TRPV Channel
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RecptorTRPC6
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Research Area——
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Indication——
Chemical Information
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CAS Number1333210-07-3
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Formula Weight367.87
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Molecular FormulaC21H22ClN3O
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Purity>98% (HPLC)
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SolubilityDMSO:350 mg/mL (951.42 mM)
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SMILESN[C@H](CCC1)CN1[C@H](Cc1c2cccc1)[C@@H]2Oc(ccc(C#N)c1)c1Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Ilatovskaya DV, et al. The Role of Angiotensin II in Glomerular Volume Dynamics and Podocyte Calcium Handling. Sci Rep. 2017 Mar 22;7(1):299.
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