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AI-10-47

CAS No. 1256094-31-1

AI-10-47( 1H-Benzimidazole, 2-(2-pyridinyl)-6-(trifluoromethoxy)-AI-10-47 )

Catalog No. M23426 CAS No. 1256094-31-1

AI-10-47 is a small molecule inhibitor of CBFβ-RUNX binding(IC50 : 3.2 μM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 90 In Stock
5MG 93 In Stock
10MG 164 In Stock
25MG 307 In Stock
50MG 433 In Stock
100MG 607 In Stock
200MG 817 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    AI-10-47
  • Note
    Research use only, not for human use.
  • Brief Description
    AI-10-47 is a small molecule inhibitor of CBFβ-RUNX binding(IC50 : 3.2 μM).
  • Description
    AI-10-47 is a small molecule inhibitor of CBFβ-RUNX binding(IC50 : 3.2 μM).
  • In Vitro
    AI-10-47 (10 μM) weakly inhibits CBFβ-RUNX binding.AI-10-47 significantly inhibits ME-1, TUR, M0-91, THP-1 and U937 cell growth. Western Blot Analysis Cell Line:4 × 106 SEM cells.Concentration:10 μM.Incubation Time:6 h.Result:Weakly reduced CBFβ binding to RUNX1 in cells (may due to its poor solubility).
  • In Vivo
    ——
  • Synonyms
    1H-Benzimidazole, 2-(2-pyridinyl)-6-(trifluoromethoxy)-AI-10-47
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    CBFβ-RUNX binding
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1256094-31-1
  • Formula Weight
    279.22
  • Molecular Formula
    C13H8F3N3O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:100 mg/mL (358.14 mM; Need ultrasonic)
  • SMILES
    FC(F)(F)OC1=CC=C2N=C(C3=NC=CC=C3)NC2=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Anuradha Illendula, et al. Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers. EBioMedicine. 2016 Jun;8:117-131.
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