Cart
sales@molnova.com
EN4 MYC inhibitor
CAS No. 1197824-15-9
EN4 MYC inhibitor( EN4 )
Catalog No. M23368 CAS No. 1197824-15-9
EN4 MYC inhibitor is a covalent ligand that targets cysteine 171 (C171) of MYC.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 65 | In Stock |
|
| 10MG | 80 | In Stock |
|
| 25MG | 177 | In Stock |
|
| 50MG | 267 | In Stock |
|
| 100MG | 402 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameEN4 MYC inhibitor
-
NoteResearch use only, not for human use.
-
Brief DescriptionEN4 MYC inhibitor is a covalent ligand that targets cysteine 171 (C171) of MYC.
-
DescriptionEN4 MYC inhibitor is a covalent ligand that targets cysteine 171 (C171) of MYC. It is selective for c-MYC over N-MYC and L-MYC, and inhibits MYC transcriptional activity, downregulates MYC targets, and impairs tumorigenesis.
-
In VitroCell Proliferation Assay Cell Line:231MFP breast cancer cells Concentration:1 μM, 10 μM, 50 μM Incubation Time:72 hours Result:Significantly impaired 231MFP breast cancer cell proliferation in a dose-dependent manner.Western Blot Analysis Cell Line:231MFP breast cancer cells Concentration:50 μM Incubation Time:60 hours Result:The protein levels of CDK2 and CDC25A were significantly lowered.
-
In VivoAnimal Model:SCID mice injected with 231MFP breast cancer cells.Dosage:50 mg/kg Administration:Intraperitoneal injection; daily; for 3 weeks Result:Significantly attenuated tumor growth in vivo.
-
SynonymsEN4
-
PathwayCell Cycle/DNA Damage
-
Targetc-Myc
-
RecptorMYC
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1197824-15-9
-
Formula Weight416.47
-
Molecular FormulaC25H24N2O4
-
Purity>98% (HPLC)
-
SolubilityDMSO:250 mg/mL (600.28 mM; Need ultrasonic)
-
SMILESCCOC1=CC=C(C=C1)OC2=CC=CC=C2NC(=O)C3=CC=C(C=C3)CNC(=O)C=C
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Lydia Boike, et al. Discovery of a Functional Covalent Ligand Targeting an Intrinsically Disordered Cysteine within MYC. Cell Chem Biol. 2021 Jan 21;28(1):4-13.e17.
molnova catalog
related products
-
BTYNB
BTYNB is a potent and selective inhibitor of IMP1 binding to c-Myc mRNA with IC50 of 5 uM.
-
Magnoflorine
Sinomeni Caulis et Rhizoma has sedative and anxiolytic effects, probably mediated by Magnoflorine through a GABAergic mechanism of action.
-
IRES-C11
A novel, spectfic c-Myc IRES (internal ribosome entry site) function inhibitor that prevents binding of hnRNP A1 to the Myc IRES and specifically inhibits Myc IRES activity in MM cells.
