Isolongifolene

Research use only, not for human use.

Isolongifolene has antioxidant, anti-inflammatory, anticancer and neuroprotective properties.

Isolongifolene has antioxidant, anti-inflammatory, anticancer and neuroprotective properties. Isolongifolene is a tricyclic sesquiterpene isolated from Murraya koenigii. Isolongifolene attenuates Rotenone-induced oxidative stress, mitochondrial dysfunction and apoptosis through the regulation of P13K/AKT/GSK-3β signaling pathways.

Isolongifolene (0-50 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment significantly alleviates Rotenone-induced cytotoxicity in SH-SY5Y cells in a dose-dependent manner.Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone-induced apoptosis in SH-SY5Y cells.Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone induced toxicity by down-regulating Bax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Furthermore regulation of p-P13K, p-AKT and p-GSK-3β expression by Isolongifolene. Cell Viability Assay Cell Line:SH-SY5Y neuroblastoma cells Concentration:0 μM, 1 μM, 2.5 μM, 5 μM, 10 μM, 20 μM and 50 μM Incubation Time:26 hours Result:Significantly alleviated Rotenone-induced cytotoxicity in SH-SY5Y cells.Apoptosis Analysis Cell Line:SH-SY5Y neuroblastoma cells Concentration:10 μMIncubation Time:26 hours Result:Attenuated Rotenone-induced apoptosis in SH-SY5Y cells.Western Blot AnalysisCell Line:SH-SY5Y neuroblastoma cells Concentration:10 μM Incubation Time:26 hours Result:Attenuated rotenone induced toxicity by down-regulatingBax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Prevented the rotenone-induced decreased phosphorylation of GSK-3β.

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(-)-Isolongifolene

Others

Other Targets

Others

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1135-66-6

204.35

C15H24

>98% (HPLC)

DMSO:10 mM

CC1(C)[C@]23CC[C@](C3)([H])C(C)(C)C2=CCC1

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(-20℃)

With Ice Pack

≥ 2 years