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XEN723
CAS No. 1072803-08-7
XEN723( —— )
Catalog No. M23280 CAS No. 1072803-08-7
XEN723 is a potent thiazolylimidazolidinone Stearoyl-CoA Desaturase (SCD1) inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 135 | In Stock |
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| 5MG | 112 | In Stock |
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| 10MG | 179 | In Stock |
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| 25MG | 304 | In Stock |
|
| 50MG | 429 | In Stock |
|
| 100MG | 603 | In Stock |
|
| 200MG | 812 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameXEN723
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NoteResearch use only, not for human use.
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Brief DescriptionXEN723 is a potent thiazolylimidazolidinone Stearoyl-CoA Desaturase (SCD1) inhibitor.
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DescriptionXEN723 is a potent thiazolylimidazolidinone Stearoyl-CoA Desaturase (SCD1) inhibitor(IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively).
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In VitroXEN723 is a novel and potent thiazolylimidazolidinone inhibitor of Stearoyl-CoA Desaturase (SCD1) with IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively. XEN723 demonstrates an improvement in SCD1 in vitro potency of more than 560-fold compare to the original high throughput screen (HTS) hit.
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In Vivo——
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetDehydrogenase
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RecptorSCD1
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Research Area——
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Indication——
Chemical Information
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CAS Number1072803-08-7
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Formula Weight425.48
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Molecular FormulaC21H20FN5O2S
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Purity>98% (HPLC)
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SolubilityDMSO:100 mg/mL (235.03 mM; Need ultrasonic)
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SMILESCc1c(C(NCc2cnccc2)=O)sc(N(CCN2Cc(cc3)ccc3F)C2=O)n1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sun S, et al. Systematic evaluation of amide bioisosteres leading to the discovery of novel and potent thiazolylimidazolidinone inhibitors of SCD1 for the treatment of metabolic diseases. Bioorg Med Chem Lett. 2014 Jan 15;24(2):520-5.
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