Cart
sales@molnova.com
Home - Products - Membrane Transporter/Ion Channel - iGluR - Sepimostat

Sepimostat

CAS No. 103926-64-3

Sepimostat( —— )

Catalog No. M23248 CAS No. 103926-64-3

Sepimostat exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 124 In Stock
5MG 112 In Stock
10MG 183 In Stock
25MG 320 In Stock
50MG 444 In Stock
100MG 607 In Stock
200MG 826 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Sepimostat
  • Note
    Research use only, not for human use.
  • Brief Description
    Sepimostat exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit.
  • Description
    Sepimostat exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat dimethanesulfonate inhibits the Ifenprodil binding with a Ki value of 27.7 μM.
  • In Vitro
    ——
  • In Vivo
    Sepimostat (1 to 100 nmol/eye, intravitreal injection) exhibits significant neuroprotective effect. Animal Model:Male Sprague Dawley rats weighing 150-300?g.Dosage:Intravitreal injection.Administration:1 to 100 nmol/eye.Result:Exhibited neuroprotective effects significantly.
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    iGluR
  • Recptor
    NR2B N-methyl-D-aspartate
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    103926-64-3
  • Formula Weight
    373.41
  • Molecular Formula
    C21H19N5O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:6.25 mg/mL?(16.74 mM;?Need ultrasonic)
  • SMILES
    C1CN=C(N1)NC2=CC=C(C=C2)C(=O)OC3=CC4=C(C=C3)C=C(C=C4)C(=N)N
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Masahiro Fuwa, et al. Nafamostat and Sepimostat Identified as Novel Neuroprotective Agents via NR2B N-methyl-D-aspartate Receptor Antagonism Using a Rat Retinal Excitotoxicity Model. Sci Rep. 2019 Dec 31;9(1):20409.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Selurampanel

    Selurampanel (BGG 492) is a selective, orally active and competitive AMPA receptor (AMPAR) antagonist with IC50 of 0.19 uM.

  • Naspm trihydrochlori...

    Naspm trihydrochloride is a synthetic analogue of Joro spider toxin and is an antagonist of calcium permeable AMPA (CP-AMPA) receptors.

  • Perampanel

    Perampanel (E2007) is a novel, orally active, noncompetitive AMPA receptor (AMPAR) antagonist with IC50 of 93 nM.

Sign In Join Free