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DUPA(OtBu)-OH

CAS No. 1026987-94-9

DUPA(OtBu)-OH( —— )

Catalog No. M23230 CAS No. 1026987-94-9

DUPA(OtBu)-OH is a DUPA precursor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 49 In Stock
2MG 29 In Stock
5MG 46 In Stock
10MG 75 In Stock
25MG 125 In Stock
50MG 170 In Stock
100MG 242 In Stock
200MG 344 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    DUPA(OtBu)-OH
  • Note
    Research use only, not for human use.
  • Brief Description
    DUPA(OtBu)-OH is a DUPA precursor.
  • Description
    DUPA(OtBu)-OH is a DUPA precursor. DUPA is used as the targeting moiety to actively deliver Docetaxel (DTX) for treatment of Prostate-Specific Membrane Antigen (PSMA) expressing prostate cancer.
  • In Vitro
    DUPA(OtBu)-OH (DUPA precursor 17) is a 2-[3-(1,3-dicarboxypropyl)ureido]pentanedioic acid (DUPA) reagent. The targeting ligand DUPA enhances the transport capability and selectivity of Paclitaxel (PTX) to tumor cells via prostate-specific membrane antigen (PSMA) mediated endocytosis. Besides, DUPA is conjugated with PTX via a disulfide bond, which facilitates the rapid and differential drug release in tumor cells.
  • In Vivo
    DUPA-targeted Docetaxel (DTX) conjugate with longer spacer has no toxicity in major organs of treated mice.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1026987-94-9
  • Formula Weight
    488.57
  • Molecular Formula
    C23H40N2O9
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:125 mg/mL (255.85 mM; Need ultrasonic)
  • SMILES
    CC(C)(C)OC(=O)CC[C@@H](C(=O)OC(C)(C)C)NC(=O)N[C@@H](CCC(=O)O)C(=O)OC(C)(C)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Roy J, et al. DUPA conjugation of a cytotoxic indenoisoquinoline topoisomerase I inhibitor for selectiveprostate cancer cell targeting. J Med Chem. 2015 Apr 9;58(7):3094-103.
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