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SCH 442416

CAS No. 316173-57-6

SCH 442416( —— )

Catalog No. M22962 CAS No. 316173-57-6

SCH-442416 is an selective antagonist of adenosine A2A receptor. SCH-442416 binds to human and rat A2A receptors with high affinity (Ki values are 0.048 and 0.5 nM respectively).The A2A receptor antagonist (SCH 442416) could increase mRNA expression of the Kir 2.1and Kir 4.1 channels in Müller cells to protect the retinal neurons in vitro under hypoxic conditions.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SCH 442416
  • Note
    Research use only, not for human use.
  • Brief Description
    SCH-442416 is an selective antagonist of adenosine A2A receptor. SCH-442416 binds to human and rat A2A receptors with high affinity (Ki values are 0.048 and 0.5 nM respectively).The A2A receptor antagonist (SCH 442416) could increase mRNA expression of the Kir 2.1and Kir 4.1 channels in Müller cells to protect the retinal neurons in vitro under hypoxic conditions.
  • Description
    SCH-442416 is an selective antagonist of adenosine A2A receptor. SCH-442416 binds to human and rat A2A receptors with high affinity (Ki values are 0.048 and 0.5 nM respectively).The A2A receptor antagonist (SCH 442416) could increase mRNA expression of the Kir 2.1and Kir 4.1 channels in Müller cells to protect the retinal neurons in vitro under hypoxic conditions.
  • In Vitro
    SCH442416 is selective for A2AR (Ki=0.50 nM) in rat striatal membranes over A1R and A3R (Ki=1815 and >10000, respectively).SCH442416 (0.1-10?μM) increases the glutamine synthetase (GS) and glutamate aspartate transporter (GLAST) proteins expression of Müller cells in Group 1?μM.
  • In Vivo
    SCH-442416 (0.017 mg/kg; i.p.) completely abrogates the CGS-21680-induced decrease in skeletal muscle injury.SCH-442416 (1 μM?2μL; i.v.) increases the GS and GLAST protein expression in rats.SCH442416 (1 μM) significantly attenuates the adenosine-induced dilation (from 15.3 to 5.6 μm).
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Adenosine Receptor
  • Recptor
    A2A
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    316173-57-6
  • Formula Weight
    389.42
  • Molecular Formula
    C20H19N7O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:Soluble
  • SMILES
    COc1ccc(cc1)CCCn2c3c(cn2)c4nc(nn4c(n3)N)c5ccco5
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kang X , Yu J , Wei Y , et al. The Effect of A 2A Receptor Antagonist (SCH 442416) on the mRNA Expression of Kir 2.1 and Kir 4.1 Channels in Rat Retinal Müller Cells Under Hypoxic Conditions in Vitro[J]. Advances in Clinical and Experimental Medicine, 2013, 22(6):825-829.
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